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1.
Proc Math Phys Eng Sci ; 474(2213): 20170608, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29887744

RESUMO

Understanding how patterns and travelling waves form in chemical and biological reaction-diffusion models is an area which has been widely researched, yet is still experiencing fast development. Surprisingly enough, we still do not have a clear understanding about all possible types of dynamical regimes in classical reaction-diffusion models, such as Lotka-Volterra competition models with spatial dependence. In this study, we demonstrate some new types of wave propagation and pattern formation in a classical three species cyclic competition model with spatial diffusion, which have been so far missed in the literature. These new patterns are characterized by a high regularity in space, but are different from patterns previously known to exist in reaction-diffusion models, and may have important applications in improving our understanding of biological pattern formation and invasion theory. Finding these new patterns is made technically possible by using an automatic adaptive finite element method driven by a novel a posteriori error estimate which is proved to provide a reliable bound for the error of the numerical method. We demonstrate how this numerical framework allows us to easily explore the dynamical patterns in both two and three spatial dimensions.

2.
J Theor Biol ; 267(4): 614-25, 2010 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-20816682

RESUMO

We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.


Assuntos
Células/metabolismo , Microtúbulos/metabolismo , Modelos Biológicos , Transporte Biológico Ativo , Difusão , Carioferinas/metabolismo , Cinética , Membrana Nuclear/metabolismo , Análise Numérica Assistida por Computador , Permeabilidade , Proteína do Retinoblastoma/metabolismo
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