RESUMO
PURPOSE: To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder. DESIGN AND METHODS: A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review. FINDINGS: One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated. PRACTICE IMPLICATIONS: Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.
Assuntos
Transtorno Bipolar/tratamento farmacológico , Indóis/farmacologia , Avaliação de Resultados em Cuidados de Saúde , Índice de Gravidade de Doença , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Indóis/administração & dosagem , Indóis/efeitos adversos , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
Psychiatric neuroimaging has made great strides. PET scanning to differentiate between the dementias is clinically useful and well accepted. Understanding of the pathophysiology underlying the psychopathology of psychiatric illness also is rapidly expanding. Neuroimaging quickly is becoming an indispensable part of the day-to-day clinical management of psychiatric patients.
