Assuntos
Emprego , Seguro Saúde , Neoplasias/economia , Neoplasias/psicologia , Adulto , Criança , HumanosRESUMO
The authors investigated the state of immunity, before and after surgery, in a group of 6 methisoprinol-treated patients and in a 10-patient control group both affected by malignant neoplasia. All the patients exhibited various degrees of immuno-depression. Versus the control group the group treated with 1-g methisoprinol injections at the dosage of 4 g daily for 7 days after surgery showed a positive effect on post-surgical immuno-depression.
Assuntos
Síndromes de Imunodeficiência/tratamento farmacológico , Inosina Pranobex/uso terapêutico , Inosina/análogos & derivados , Neoplasias/cirurgia , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Humanos , Síndromes de Imunodeficiência/etiologia , Síndromes de Imunodeficiência/prevenção & controle , Complicações Pós-OperatóriasRESUMO
A double-blind trial was carried out comparing the effects of decanoates of flupenthixol and fluphenazine on the symptoms, ward behaviour and functional capacity in occupational therapy in 51 chronic schizophrenic patients. The patients were carefully selected on the basis of rigid criteria for diagnoses. To exclude nonresponders to neuroleptics the patients were first taken off neuroleptic drugs and only those who appeared to show deterioration were included in the trial. The dosage of drugs was varied according to clinical indications. The length of the trial was initially 4 months and 31 patients were followed for an additional 4 months. To ensure reliability multiple assessments were made at the start and the end of the trial. Most of the statistical tests showed no differences between the treatments, but some of those relating to affective symptoms showed an advantage for flupenthixol as compared with fluphenazine. There were no differences in the incidence of extra-pyramidal side-effects which required treatment in only 32% of the patients on each drug.