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1.
Ital J Pediatr ; 41: 26, 2015 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-25888518

RESUMO

Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant's cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.


Assuntos
Antivirais/farmacologia , Antivirais/uso terapêutico , Infecções por Citomegalovirus/líquido cefalorraquidiano , Infecções por Citomegalovirus/congênito , Ganciclovir/análogos & derivados , Adulto , Antivirais/administração & dosagem , DNA Viral/análise , Feminino , Ganciclovir/administração & dosagem , Ganciclovir/farmacologia , Ganciclovir/uso terapêutico , Humanos , Recém-Nascido , Gravidez , Complicações Infecciosas na Gravidez , Valganciclovir
2.
Int J Environ Res Public Health ; 10(2): 699-711, 2013 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-23435591

RESUMO

The aim of this study was to characterize the placental transfer of some environmental pollutants, and to explore the possibility of quantitatively predicting in utero exposure to these contaminants from concentrations assessed in maternal blood. Levels of toxic substances such as pesticides (p,p'-DDE, ß-HCH, and HCB), polychlorinated biphenyls (PCBs), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA) were determined in serum samples of 38 pregnant women living in Rome and in samples of cord blood from their respective newborns. The study was carried out in the years 2008-2009. PCB mean concentrations in maternal serum and cord serum ranged from 0.058 to 0.30, and from 0.018 to 0.064 ng/g · fw respectively. Arithmetic means of PFOS and PFOA concentrations in mothers and newborns were 3.2 and 1.4 ng/g · fw, and 2.9 and 1.6 ng/g · fw. A strong correlation was observed between concentrations in the maternal and the foetal compartment for PFOS (Spearman r = 0.74, p < 0.001), PFOA (Spearman r = 0.70, p < 0.001), PCB 153 (Spearman r = 0.60, p < 0.001), HCB (Spearman r = 0.68, p < 0.001), PCB 180 (Spearman r = 0.55, p = 0.0012), and p,p'-DDE (Spearman r = 0.53, p = 0.0099). A weak correlation (p < 0.1) was observed for PCBs 118 and 138.


Assuntos
Poluentes Ambientais/sangue , Sangue Fetal/química , Exposição Materna , Troca Materno-Fetal , Gravidez/sangue , Adulto , Ácidos Alcanossulfônicos/sangue , Caprilatos/sangue , Monitoramento Ambiental , Feminino , Fluorocarbonos/sangue , Humanos , Hidrocarbonetos Clorados/sangue , Recém-Nascido , Pessoa de Meia-Idade , Praguicidas/sangue , Placenta , Circulação Placentária , Análise de Regressão
3.
J Matern Fetal Neonatal Med ; 25 Suppl 3: 21-5, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23016613

RESUMO

Early onset sepsis (EOS) is a severe problem affecting very low birth weight (VLBW) infants and is associated with a threefold increased risk of mortality. Although advances in perinatal care have led to improved survival of VLBW infants over recent decades, survival without major neonatal morbidity has not increased. The authors reviewed the current literature on EOS, focusing on the peculiarities concerning risk factors, etiology, diagnosis, treatment and outcome in very low birth weight infants, and on the recent advances in the management of this condition.


Assuntos
Doenças do Prematuro/tratamento farmacológico , Sepse/tratamento farmacológico , Humanos , Recém-Nascido , Doenças do Prematuro/diagnóstico , Doenças do Prematuro/epidemiologia , Recém-Nascido de muito Baixo Peso , Fatores de Risco , Sepse/diagnóstico , Sepse/epidemiologia , Resultado do Tratamento
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