Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Dor Musculoesquelética/epidemiologia , Dor Musculoesquelética/prevenção & controle , Dor Musculoesquelética/terapia , Autocuidado/métodos , Autocuidado/tendências , Qualidade de Vida , Terapia Cognitivo-Comportamental/métodos , Terapia Cognitivo-Comportamental/tendências , Inquéritos e QuestionáriosRESUMO
Fundamento y objetivo: El síndrome de Löfgren se caracteriza por adenopatías hiliares, eritema nudoso y artritis. Es una variante benigna de sarcoidosis, frecuente en la región mediterránea. El objetivo de este estudio fue describir las características clínicas, el tratamiento y la evolución de una serie de pacientes diagnosticados de síndrome de Löfgren. Pacientes y método: Estudio retrospectivo (1984-2013) en 2 hospitales universitarios con un área total de referencia de 1.015.000 habitantes. Resultados: Se diagnosticaron 80 pacientes, 29 varones y 51 mujeres, con una media de edad de 42,3 años. Cuarenta y ocho pacientes (60%) presentaron la tríada clásica de la enfermedad: adenopatías hiliares, artritis y eritema nudoso; 18 (22%), adenopatías hiliares y artritis; y 13 (16%), adenopatías hiliares y eritema nudoso. Todos presentaron alteraciones en el estudio del tórax y se clasificaron dentro del estadio I-II. Se realizaron 39 biopsias, siendo características de sarcoidosis 28 (35%). El tratamiento realizado consistió en antiinflamatorios no esteroideos (54 pacientes, 67%) y glucocorticoides (33 pacientes, 41%). Catorce pacientes (17%) presentaron recaída de la enfermedad. Conclusiones: El síndrome de Löfgren es una forma benigna de sarcoidosis con un patrón clínico característico. En pocas ocasiones requiere confirmación histológica, y tiene un buen pronóstico (AU)
Background and objective: Löfgren syndrome is characterized by hilar lymphadenopathy, erythema nodosum and arthritis. It is a benign variant of sarcoidosis, common in the Mediterranean region. The aim of this study was to describe the clinical characteristics, treatment and outcome in a series of patients diagnosed with Löfgren syndrome. Patients and methods: A retrospective study (1984-2013) in 2 university hospitals with a total catchment area of 1,015,000 inhabitants. Results 80 patients, 29 men and 51 women were diagnosed with a mean age of 42.3 years. Forty-eight patients (60%) had the classic triad of the disease: hilar lymphadenopathy, arthritis and erythema nodosum; 18 (22%), hilar lymphadenopathy, and arthritis; and 13 (16%), hilar lymphadenopathy and erythema nodosum. All had abnormalities in the study of the chest and were classified in stage I-II. 39 biopsies were performed, with characteristics of sarcoidosis 28 (35%). The treatment performed was to nonsteroidal antiinflammatory drugs (54 patients, 67%) and glucocorticoids (33 patients, 41%). Fourteen patients (17%) had relapsed disease. Conclusions: Löfgren's syndrome is a benign form of sarcoidosis with a characteristic clinical pattern. Rarely requires histologic confirmation, and has a good prognosis (AU)
Assuntos
Humanos , Sarcoidose Pulmonar/epidemiologia , Eritema Nodoso/epidemiologia , Artrite/epidemiologia , Estudos Retrospectivos , Anti-Inflamatórios não Esteroides/uso terapêutico , Glucocorticoides/uso terapêuticoRESUMO
BACKGROUND AND OBJECTIVE: Löfgren's syndrome is characterized by hiliar adenopathies, erythema nodosum and arthritis. It is a benign variant of sarcoidosis, common in the Mediterranean area. To describe the clinical characteristics, treatment and outcome of a series of patients diagnosed with Löfgren's syndrome. PATIENTS AND METHODS: Retrospective design (1984-2013). SETTING: Two university hospitals with a reference population of 1,015,000 inhabitants. RESULTS: Eighty patients were diagnosed: 29 men and 51 women (mean age 42.3 years). Forty eight patients (60%) presented with the classical triad: hiliar adenopathies, erythema nodosum and arthritis; 18 (22%) with hiliar adenopathy and arthritis; 13 (16%) hiliar adenopathies and erythema nodosum. All showed abnormalities in the chest study. According to the radiological pattern, patients were classified in stage i-ii. Biopsy was performed in 39 patients and was diagnostic in 28. Treatment was based on non-steroidal anti-inflammatory drugs (54 patients, 67%) and corticosteroids (33 patients, 41%). Fourteen patients (17%) suffered a recurrence of the disease. CONCLUSIONS: Löfgren's syndrome is a benign form of sarcoidosis with a well defined clinical pattern. Biopsy is usually not required. Recurrence is scarce. The disease has a good prognosis.
