RESUMO
Introducción: Los estudiantes universitarios se ven envueltos en situaciones de estrés y ansiedad que afectan su proceso académico y calidad de vida. Sin el acompañamiento adecuado, el estrés puede desencadenar en problemas psicológicos mayores, tales como el Síndrome de Burnout. Objetivo: Identificar la prevalencia del Síndrome de Burnout en estudiantes de medicina de una institución universitaria en Cartagena durante el primer período del año 2019. Materiales y Métodos: Estudio descriptivo de tipo cuantitativo, la población fueron estudiantes del programa de medicina de una institución universitaria de Cartagena, matriculados en el primer período del año 2019, se aplicó el test de Maslach Burnout Inventory Student Survey (MBI-SS-1981), el cual mide tres parámetros indicadores de Síndrome de Burnout. Resultados: Se realizaron 383 encuestas, el 63% fueron de género femenino, el 91,7% son solteros, el 53% está entre los 20 y los 25 años, la prevalencia del Síndrome de Burnout fue de 30.8%. Conclusión: El Síndrome de Burnout en los estudiantes del programa de medicina de la institución Universitaria de la ciudad de Cartagena presenta una prevalencia importante, por tanto, es necesario diseñar estrategias que permitan su prevención.
Introduction: University students are involved in situations of stress and anxiety that affect their academic process and quality of life. Without the proper accompaniment, stress can trigger major psychological problems, such as Burnout Syndrome. Objective: To identify the prevalence of Burnout Syndrome in medical students of a university institution in Cartagena during the first period of 2019. Materials and Methods: Descriptive quantitative study, the population were students of the medicine program of a university institution in Cartagena, enrolled in the first period of 2019, the Maslach Burnout Inventory Student Survey (MBI-SS-1981) test was applied, which measures three indicator parameters of Burnout Syndrome.. Results: 383 surveys were carried out, 63% were female, 91.7% are single, 53% are between 20 and 25 years old, the prevalence of Burnout Syndrome was 30.8%. Conclusion: The Burnout Syndrome in the students of the medicine program of the University institution of the city of Cartagena presents an important prevalence, therefore, it is necessary to design strategies that allow its prevention.
RESUMO
BACKGROUND: Invasive meningococcal disease has its highest incidence in infants. Co-administration of serogroup B (4CMenB) and quadrivalent conjugate (MenACWY-CRM) vaccines could protect against 5 clinically-relevant meningococcal serogroups. METHODS: This phase 3b, open, multicenter study (NCT02106390), conducted in Mexico and Argentina, enrolled and randomized (1:1:1) 750 healthy infants to receive either 4CMenB co-administered with MenACWY-CRM (4CMenB/MenACWY group), 4CMenB (4CMenB group), or MenACWY-CRM alone (MenACWY group) at ages 3, 5, 7 and 13â¯months. Non-inferiority of immune responses of co-administration to single administration of vaccines was assessed at 1â¯month post-booster dose (primary objective). Immunogenicity was evaluated pre- and 1â¯month post-primary and booster vaccinations using human serum bactericidal assay (hSBA). Safety was assessed. RESULTS: At 1â¯month post-booster vaccination, between-group hSBA geometric mean titer (GMT) ratios ranged from 0.89 to 1.03 for serogroup B strains (group 4CMenB/MenACWY over 4CMenB), and from 1.05 to 2.48 for ACWY serogroups (group 4CMenB/MenACWY over MenACWY). The lower limit of the 2-sided 95% confidence intervals for all GMT ratios was >0.5; the primary objective was demonstrated. Across all groups and serogroup B strains, 68-100% and 87-100% of children had hSBA titers ≥5 at 1â¯month post-primary and booster vaccination, respectively. For serogroups ACWY, ≥96% (post-primary vaccination) and ≥98% (post-booster vaccination) of children in all groups had hSBA titers ≥4. Post-booster vaccination, GMTs increased ≥5.99-fold from pre-booster values for each strain/serogroup. Solicited adverse events (AEs) were more frequent in groups 4CMenB/MenACWY and 4CMenB than in MenACWY; incidence of all other AEs was similar between groups. Serious AEs were reported for 6, 13, and 11 participants in groups 4CMenB/MenACWY, 4CMenB, and MenACWY, respectively; 1 (group 4CMenB) was considered vaccine-related. CONCLUSION: Immune responses elicited by co-administration of 4CMenB and MenACWY-CRM was non-inferior to single immunization. Co-administration of vaccines was immunogenic and well tolerated in infants. ClinicalTrials.gov: NCT02106390.
