1.
Chemistry
; 24(13): 3117-3121, 2018 Mar 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29193385
RESUMO
A new organocatalytic strategy for the synthesis of enantioenriched aza-Baylis-Hillman type products via a frustrated vinylogous reaction is presented. This process proceeds under mild conditions with good yields, completed Z/E selectivity and excellent enantioselectivities. Moreover, easy derivatizations of the final products led to important building blocks of organic synthesis such as 1,3-aminoalcohols and Lewis base catalysts.