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Stat Methods Med Res ; 12(4): 333-49, 2003 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12939100

RESUMO

We propose a fully parametric model for the analysis of competing risks data where the types of failure may not be independent. We show how the dependence between the cause-specific survival times can be modelled with a copula function. Features include: identifiability of the problem; accessible understanding of the dependence structures; and flexibility in choosing marginal survival functions. The model is constructed in such a way that it allows us to adjust for concomitant variables and for a dependence parameter to assess the effects of these on each marginal survival model and on the relationship between the causes of death. The methods are applied to a prostate cancer data set. We find that, with the copula model, more accurate inferences are obtained than with the use of a simpler model such as the independent competing risks approach.


Assuntos
Modelos de Riscos Proporcionais , Medição de Risco/estatística & dados numéricos , Análise de Sobrevida , Humanos , Masculino , Neoplasias da Próstata/mortalidade , Neoplasias da Próstata/patologia , Falha de Tratamento
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