Do complaints of everyday cognitive failures in high schizotypy relate to emotional working memory deficits in the lab?

BACKGROUND: Individuals high on schizotypy complain of increased cognitive failures in everyday life. However, the neuropsychological performance of this group does not consistently indicate underlying ability deficits. It is possible that current neuropsychological tests lack ecological validity. Given the increased affective reactivity of high schizotypes, they may be more sensitive to emotional content interfering with cognitive ability. This study sought to explore whether an affective n-back working memory task would elicit impaired performance in schizotypy, echoing complaints concerning real world cognition. METHODS: 127 healthy participants completed self-report measures of schizotypy and cognitive failures and an affective n-back working memory task. This task was varied across three levels of load (1- to 3-back) and four types of stimulus emotion (neutral, fearful, happy, sad). Differences between high (n=39) and low (n=48) schizotypy groups on performance outcomes of hits and false alarms were examined, with emotion and load as within-groups variables. RESULTS: As expected, high schizotypes reported heightened vulnerability to cognitive failures. They also demonstrated a relative working memory impairment for emotional versus neutral stimuli, whereas low schizotypes did not. High schizotypes performed most poorly in response to fearful stimuli. For false alarms, there was an interaction between schizotypy, load, and emotion, such that high schizotypy was associated with deficits in response to fearful stimuli only at higher levels of task difficulty. Inclusion of self-reported cognitive failures did not account for this. CONCLUSION: These findings suggest that the "gap" between subjective and objective cognition in schizotypy may reflect the heightened emotional demands associated with cognitive functioning in the real world, although other factors also seem to play a role. There is a need to improve the ecological validity of objective assessments, whilst also recognizing that self-reported cognitive failures tap into a range of factors difficult to assess in the lab, including emotion. Cognitive interventions for at-risk individuals will likely be more beneficial if they address emotional processing alongside other aspects of cognition.

Schizotypy and Cognitive Failures: A Mediating Role for Affect.

BACKGROUND: Cognitive failures are disruptions in cognitive functioning during everyday life. Vulnerability to these failures is increased in a range of psychological disorders, including schizophrenia. In addition, healthy individuals with personality-based psychosis proneness, or schizotypy, often complain of heightened failures. A factor known to exacerbate cognitive failures is negative affect. Negative affectivity is linked to both schizophrenia and schizotypy. It is therefore possible that affect is responsible for the increased everyday cognitive failures in "high schizotypes". This poses 2 possibilities: are cognitive failures only present in high schizotypes who also have negative affect (moderation)? Or does negative affect account for the relationship between schizotypy and cognitive failures (mediation)? We sought to explore whether negative affect mediates or moderates the relationship between schizotypy and cognitive failures in young adults. SAMPLING AND METHODS: Healthy young adults from a student and community sample (n = 863, 71% female) aged 18-25 years (mean = 19.5, SD = 1.87) completed online questionnaires measuring self-report schizotypy, negative affect, and cognitive failures. Moderation and mediation analyses were carried out using the PROCESS macro in SPSS to examine how negative affect exerted its effect on the relationship between schizotypy and cognitive failures. RESULTS: All 3 factors were positively correlated. Negative affect was not a moderator for the relationship between schizotypy and cognitive failures; however, it did partially mediate this relationship. CONCLUSIONS: Our findings suggest that whilst schizotypy and negative affect do not interact to produce cognitive failures, negative affect contributes to (but does not fully account for) the mechanism by which schizotypy increases failures in young adults. Other, as yet unidentified, facets of schizotypy also appear to contribute to cognitive failures. In attempting to address the cognitive complaints of at-risk individuals, clinicians need to be aware of the role of negative affect and other pertinent aspects of schizotypy.

A systematic review of the relationship between psychological disorders or substance use and self-reported cognitive failures.

INTRODUCTION: Cognitive failures are errors in normal everyday functioning. Individuals with psychological disorders may possess heightened vulnerability. We sought to review the literature on cognitive failures in psychological disorders to determine the nature of this association, and whether failures relate to neuropsychological performance. We also examine the relationship between cognitive failures and substance use since it is relevant to everyday cognition and co-occurs in many psychological disorders. METHODS: We conducted a systematic review of self-reported cognitive failures in psychological disorders and substance use, identifying 21 papers in total. RESULTS: Papers identified studied trauma, mood, and anxiety disorders, and schizophrenia. Substance use papers included nicotine, alcohol, cannabis, and ecstasy use. Cognitive failures were increased in some but not all papers; the most consistent findings were for depression, PTSD, and daily smokers of nicotine. Subjective failures did not correlate closely with neuropsychological outcomes in any disorders. We were unable to discern distinct profiles of failures for each disorder; rather they may reflect emotional dysregulation more broadly. CONCLUSIONS: The real world cognitive experiences of people with psychological disorders may differ to their performance in the clinic or lab. It is important that self-reports of minor cognitive issues are considered as both a potential risk and a maintaining factor of illness. Substance use also needs to be considered in assessing cognitive failures.

A systematic review of cognitive failures in daily life: Healthy populations.

Cognitive failures are minor errors in thinking reported by clinical and non-clinical individuals during everyday life. It is not yet clear how subjectively-reported cognitive failures relate to objective neuropsychological ability. We aimed to consolidate the definition of cognitive failures, outline evidence for the relationship with objective cognition, and develop a unified model of factors that increase cognitive failures. We conducted a systematic review of cognitive failures, identifying 45 articles according to the PRISMA statement. Failures were defined as reflecting proneness to errors in 'real world' planned thought and action. Vulnerability to failures was not consistently associated with objective cognitive performance. A range of stable and variable factors were linked to increased risk of cognitive failures. We conclude that cognitive failures measure real world cognitive capacity rather than pure 'unchallenged' ability. Momentary state may interact with predisposing trait factors to increase the likelihood of failures occurring. Inclusion of self-reported cognitive failures in objective cognitive research will increase the translational relevance of ability into more ecologically valid aspects of real world functioning.