[Waist circumference as a predictor of insulin resistance in young men]. / Circunferencia de la cintura como predictor de resistencia insulínica en varones jóvenes.

BACKGROUND AND OBJECTIVE: Waist circumference (WC) is a measure of upper body fat and so should be useful for identifying overweight and obese men at risk of developing metabolic complications. The objective was to determine the relations of WC to cardiovascular risk factors in a sample of young men and to assess the clinical relevance of WC in identifying insulin resistance. SUBJECTS AND METHOD: This study included 194 male Spanish subjects aged 26 (5) years who were divided in 3 groups according to the WC: Normal (< 94 cm), moderate risk (> or = 94 cm) and elevated risk (> or = 102 cm). Body mass index (BMI), WC, blood pressure, serum levels of total cholesterol, triglycerides (TG), HDL-cholesterol, LDL-cholesterol, glucose, uric acid and insulin were measured by standard methods. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMAIR). RESULTS: The prevalence of overweight and obesity was 46.9% and 6.7% respectively. Men with moderate and elevated risk showed higher concentrations of glucose (p < 0.004), uric acid (p < 0.001), TG (p < 0.001), LDL-cholesterol/HDL-cholesterol index (p < 0.001), insulin (p < 0.001) and HOMAIR (p < 0.001). WC was significantly correlated with age (r = 0,282; p < 0.001), TG (r = 0.308; p < 0,001), insulin (r = 0.282; p < 0.001) and HOMAIR (r = 0.281; p < 0.001). A multivariate linear correlation analysis showed that HOMAIR was significantly associated with WC (p < 0.009) and TG (p < 0.003; r2 = 0.13). CONCLUSIONS: WC of these young men was independently associated with certain cardiovascular risk factors, in particular insulin resistance. This suggests that WC may be reasonably included in clinical practice as a simple tool that may help identify sub-groups of overweight or obese young men at higher metabolic risk.

Circunferencia de la cintura como predictor de resistencia insulínica en varones jóvenes / Waist circumference as a predictor of insulin resistance in young men

Fundamento y objetivo: La circunferencia de la cintura (CC) es una medida de la grasa visceral que podría ser útil para identificar a las personas con sobrepeso u obesidad que tienen riesgo de desarrollar complicaciones metabólicas. El objetivo de este estudio fue determinar las relaciones de la CC con los factores de riesgo cardiovascular en varones jóvenes y evaluar la relevancia clínica de la CC en la identificación de resistencia a la insulina. Sujetos y método: Se estudió a 194 varones españoles jóvenes (edad media [desviación estándar] 26 [5] años) que fueron divididos en 3 grupos según la CC: normal (= 94 cm) y riesgo elevado (>= 102 cm), en los que se midieron el índice de masa corporal, la CC, la presión arterial, las concentraciones plasmáticas de colesterol total, los triglicéridos (TG), el colesterol unido a lipoproteínas de alta densidad (cHDL), el colesterol unido a lipoproteínas de baja densidad (cLDL), la glucosa, el ácido úrico y la insulina, por los métodos estandarizados. Para estimar el grado de resistencia a la insulina se aplicó el modelo homeostático (HOMAIR). Resultados: La prevalencia de sobrepeso y obesidad fue del 46,9 y 6,7% respectivamente. Los varones con riesgo moderado y elevado mostraron concentraciones plasmáticas más altas de glucosa (p < 0,004), ácido úrico (p < 0,001), TG (p < 0,001), índice cLDL-cHDL (p < 0,001), insulina (p < 0,001) y HOMAIR (p < 0,001). La CC se correlacionó significativamente con la edad (r = 0,282, p < 0,001), TG (r = 0,308; p < 0,001), insulina (r = 0,280; p < 0,001) y HOMAIR (r = 0,281; p < 0,001). El análisis de correlación linear multivariante demostró que el índice HOMAIR estaba significativamente asociado con la CC (p < 0,009) y la concentración de TG (p < 0,003; r2 = 0,13). Conclusiones: La CC estuvo asociada a ciertos factores de riesgo cardiovascular y en particular a la resistencia a la insulina, lo que indica que podría incluirse en la práctica clínica como una herramienta que ayude a identificar a subgrupos de varones jóvenes con sobrepeso u obesidad y mayor riesgo metabólico

Background and objective: Waist circumference (WC) is a measure of upper body fat and so should be useful for identifying overweight and obese men at risk of developing metabolic complications. The objective was to determine the relations of WC to cardiovascular risk factors in a sample of young men and to assess the clinical relevance of WC in identifying insulin resistance. Subjects and method: This study included 194 male Spanish subjects aged 26 (5) years who were divided in 3 groups according to the WC: Normal (= 94 cm) and elevated risk (>= 102 cm). Body mass index (BMI), WC, blood pressure, serum levels of total cholesterol, triglycerides (TG), HDL-cholesterol, LDL-cholesterol, glucose, uric acid and insulin were measured by standard methods. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMAIR). Results: The prevalence of overweight and obesity was 46.9% and 6.7% respectively. Men with moderate and elevated risk showed higher concentrations of glucose (p < 0.004), uric acid (p < 0.001), TG (p < 0.001), LDL-cholesterol/HDL-cholesterol index (p < 0.001), insulin (p < 0.001) and HOMAIR (p < 0.001). WC was significantly correlated with age (r = 0,282; p < 0.001), TG (r = 0.308; p < 0,001), insulin (r = 0.282; p < 0.001) and HOMAIR (r = 0.281; p < 0.001). A multivariate linear correlation analysis showed that HOMAIR was significantly associated with WC (p < 0.009) and TG (p < 0.003; r2 = 0.13). Conclusions: WC of these young men was independently associated with certain cardiovascular risk factors, in particular insulin resistance. This suggests that WC may be reasonably included in clinical practice as a simple tool that may help identify sub-groups of overweight or obese young men at higher metabolic risk