[Glucose metabolism alterations and follow-up study of a non-diabetic adult population]. / Alteraciones del metabolismo de la glucosa y estudio de seguimiento de una población adulta no diabética.

OBJECTIVE: To determine the appearance of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) at five years of follow-up in a known non-diabetic population. DESIGN: nested case control studies (case s-control into a cohort) developed in two stages: 1) identification and characterization of the cohort and 2) follow-up. STUDY POPULATION: representative sample of a non-diabetic population between 40 and 75 years old attended in a Primary Health Center. IDENTIFICATION: 326 persons, 2.1% of whom were diagnosed of previously unknown DM2 and 7.3% of IFG. Insulin resistance (IR) was higher in patients with IFG and pancreatic function of beta cells (PFBC) was higher in the population without glucose metabolism alteration. FOLLOW-UP: 121 persons, 9.7 % of whom evolved to DM2 (all with IFG). IFG proportion at the end of the follow-up was 23.96%. CONCLUSIONS: At 5 years of follow-up, more than 1/3 of the population studied developed DM2 or IFG. These diagnoses were related with IR and PFBC.

Alteraciones del metabolismo de la glucosa y estudio de seguimiento de una población adulta no diabética / Glucose metabolism alterations and follow-up study of a non-diabetic adult population

Objetivo. Determinar la aparición de diabetes mellitus (DM) y glucemia basal alterada (GBA) a los cinco años de seguimiento de una población no diabética conocida. Material y métodos. Diseño: estudio casos-control anidado (casos-control dentro de una cohorte) desarrollado en dos fases, la de identificación y caracterización de la cohorte a estudio y la de seguimiento. Población a estudio: muestra representativa de población no diabética de 40 a 75 años atendida en un Centro de Atención Primaria. Resultados. Fase de identificación: 326 personas de las que un 2,1% fueron diagnosticadas de DM2 no conocida previamente y un 7,3% de GBA. La resistencia a la insulina (RI) fue superior en los pacientes con GBA y la función de la célula beta pancreática (FBP) fue superior en la población sin alteraciones del metabolismo de la glucosa. Fase de seguimiento: 121 personas. Un 9,7% evolucionaron a DM2 (todos con GBA previa) siendo la proporción de GBA al final del seguimiento de 23,96%. Conclusiones. A los cinco años de seguimiento, más de un tercio de la población estudiada evolucionó a DM o a GBA, estando la aparición de estas alteraciones relacionada con la RI y con la FBP (AU)

Objective. To determine the appearance of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) at five years of follow-up in a known non-diabetic population. Patients and methods. Design: nested case control studies (case s-control into a cohort) developed in two stages: 1) identification and characterization of the cohort and 2) follow-up. Study population: representative sample of a non-diabetic population between 40 and 75 years old attended in a Primary Health Center. Results. Identification: 326 persons, 2.1% of whom were diagnosed of previously unknown DM2 and 7.3% of IFG. Insulin resistance (IR) was higher in patients with IFG and pancreatic function of beta cells (PFBC) was higher in the population without glucose metabolism alteration. Follow-up: 121 persons, 9.7 % of whom evolved to DM2 (all with IFG). IFG proportion at the end of the follow-up was 23.96%. Conclusions. At 5 years of follow-up, more than 1/3 of the population studied developed DM2 or IFG. These diagnoses were related with IR and PFBC (AU)