[Development of a myasthenia crisis during interferon treatment for chronic C hepatitis]. / Survenue d'une crise myasthénique au cours du traitement par interféron d'une hépatite virale C.

If myasthenia gravis is not a usual complication of interferon therapy, several cases have been described with the use of theses molecules in the treatment of hepatitis C, cancer or multiple sclerosis. We report a new case of serious myasthenia gravis during interferon alpha and ribavirin therapy for hepatitis C.

[Macrophage activation syndrome after treatment with infliximab for fistulated Crohn's disease]. / Syndrome d'activation macrophagique après traitement par infliximab pour maladie de Crohn fistulisée.

INTRODUCTION: Macrophage activation syndrome has never been reported as an adverse effect of infliximab. CASE: Treatment with infliximab was prescribed for a 37-year-old man with fistulated Crohn's disease unresponsive to azathioprine. Three months after the last injection, he developed macrophagic activation syndrome, with febrile pancytopenia, hyperferritinemia, hypertriglyceridemia and an activated cephalin time twice the control level. DISCUSSION: Elimination of the known causes of macrophage activation syndrome suggests it is related to the infliximab treatment, but its pathogenesis remains a mystery.