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Nutr Cancer ; 61(5): 708-16, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19838945

RESUMO

This study examined the relation of soy intake with hormonal and proliferation markers in benign and malignant breast tissue using tissue microarrays (TMAs). TMAs with up to 4 malignant and 4 benign tissue samples for 268 breast cancer cases were constructed. Soy intake in early life and in adulthood was assessed by questionnaire. The TMAs were stained for estrogen receptor (ER) alpha, ERbeta, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/neu), proliferating cell nuclear antigen (PCNA), and Ki-67 using standard immunohistochemical methods. Logistic regression was applied for statistical analysis. A higher percentage of women showed positive marker expression in malignant than in benign tissue. With one exception, HER2/neu, no significant associations between soy intake and pathologic markers were observed. Early life soy intake was associated with lower HER2/neu and PCNA staining of malignant tissue. In benign tissue, early life soy intake showed higher ER and PR expression, but no difference in proliferation markers. The results of this investigation provide some assurance that soy intake does not adversely affect markers of proliferation. TMAs were shown to be a useful tool for epidemiologic research.


Assuntos
Anticarcinógenos/administração & dosagem , Biomarcadores Tumorais/análise , Neoplasias da Mama/patologia , Mama/química , Alimentos de Soja , Análise Serial de Tecidos/métodos , Idoso , Envelhecimento , Índice de Massa Corporal , Neoplasias da Mama/química , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/etnologia , Inquéritos sobre Dietas , Receptores ErbB/análise , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-67/análise , Modelos Logísticos , Pessoa de Meia-Idade , Antígeno Nuclear de Célula em Proliferação/análise , Receptores de Estrogênio/análise , Receptores de Progesterona/análise , Alimentos de Soja/efeitos adversos , Alimentos de Soja/estatística & dados numéricos
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