RESUMO
Shift work has become more and more common for the last thirty years. By definition, shift work disturbs the circadian rhythm and the internal clock. Even if the pathophysiological mechanisms are not well understood, a greater cardiovascular risk has been attributed to shift work. Cross-sectional and cohort studies have identified an association between shift work and an elevated blood pressure. Shift workers also present a higher incidence of hypertension and progression than day workers. Unfortunately, the heterogeneity of the studies, the multiple confounding factors, as well as the complexity to achieve a suitable comparison group make it impossible to draw firm clinical evidence. Nevertheless, this population needs a medical follow-up focused on the cardiovascular risks and blood pressure.
Assuntos
Ritmo Circadiano , Hipertensão/epidemiologia , Hipertensão/etiologia , Tolerância ao Trabalho Programado , Determinação da Pressão Arterial/métodos , Progressão da Doença , Medicina Baseada em Evidências , Humanos , Hipertensão/fisiopatologia , Incidência , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Suíça/epidemiologiaRESUMO
The crucial role of the sympathetic nervous system activity in the initiation and maintenance of hypertension was already in mind in the 1920s when surgical options were proposed to severely hypertensive patients. Despite constant evolution of pharmacological treatments, one estimates that 15-30% of hypertensive patients are still not well controlled and present resistant hypertension. The development of a new endovascular catheter used for selective sympathetic renal denervation by radiofrequency offers new perspectives of treatment. Encouraged by the recent results of the first clinical trials in a targeted population, this procedure could be used in some more indications in the future. However, long term morbidity and mortality of this technique are still not known.
Assuntos
Ablação por Cateter , Hipertensão/cirurgia , Rim/cirurgia , Simpatectomia , Ablação por Cateter/métodos , Ensaios Clínicos como Assunto , Humanos , Simpatectomia/métodos , Resultado do TratamentoRESUMO
The discovery in 1988 of endothelin, the most potent human endogenous vasoconstrictor, has opened the race to the discovery of a new weapon against arterial hypertension. The development of the endothelin receptors antagonists (ERAs) and the demonstration of their efficacy in preclinical models initially raised a wave of enthusiasm, which was however tempered due to their unfavorable side effect profile. In this article we will review the phases of the development ERAs, and their current and future place as therapeutic tool against arterial hypertension.
Assuntos
Anti-Hipertensivos/uso terapêutico , Antagonistas dos Receptores de Endotelina , Hipertensão/tratamento farmacológico , Anti-Hipertensivos/farmacologia , Medicina Baseada em Evidências , Humanos , Hipertensão/metabolismo , Resultado do TratamentoRESUMO
The effects of drugs on new cancer and cancer-related death are a major concern. Recently, a meta-analysis raised the possibility that ARBs might have an adverse impact in this respect. This point of view was highly debated until the publication of two other meta-analyses which did not demonstrate any increased risk of new cancer occurrence as well as of cancer related-death with the use of ARBs in patients with hypertension, heart failure and/or nephropathy. This illustrates that the results of meta-analyses should be interpreted cautiously and critically in order to avoid biased conclusions. Overall the bulk of evidence today indicates that ARBs are not associated with an increased cancer risk.