RESUMO
Rarely screened in psychiatric patients, primary and/or secondary Carnitine deficiency could be influencing and/or mimicking the mood symptoms of our patient population. The brain and specifically neurons are highly vulnerable to impairments in oxidative metabolism, which can lead to neuronal cell death and disorders of neurotransmitters causing changes in cognition and behavior. For this reason, identification of this disorder is important since its treatment could result in symptom improvement and better quality of life of our patients. We present a case where exacerbation of mood symptoms was associated to primary and secondary Carnitine deficiency.
Assuntos
Antimaníacos/efeitos adversos , Transtorno do Deficit de Atenção com Hiperatividade/complicações , Carnitina/deficiência , Hiperamonemia/psicologia , Complexo Cetoglutarato Desidrogenase/antagonistas & inibidores , Transtornos do Humor/complicações , Proteínas de Transporte de Cátions Orgânicos/deficiência , Ácido Valproico/efeitos adversos , Adulto , Antidepressivos/uso terapêutico , Transtorno do Deficit de Atenção com Hiperatividade/sangue , Benzodiazepinas/uso terapêutico , Carnitina/uso terapêutico , Citalopram/uso terapêutico , Transtorno Depressivo/complicações , Transtorno Depressivo/tratamento farmacológico , Transtornos Disruptivos, de Controle do Impulso e da Conduta/complicações , Substituição de Medicamentos , Quimioterapia Combinada , Humanos , Hiperamonemia/induzido quimicamente , Hiperamonemia/genética , Lorazepam/uso terapêutico , Masculino , Transtornos do Humor/sangue , Olanzapina , Proteínas de Transporte de Cátions Orgânicos/genética , Membro 5 da Família 22 de Carreadores de Soluto , Ácido Valproico/farmacologia , Ácido Valproico/uso terapêuticoRESUMO
Exacerbation of symptoms in mood disorders such as bipolar disorders, major depressive disorders and premenstrual dysphoric disorders could be influenced by the hormonal changes of the menstrual cycles in female patients. Menarche has been related to onset of mood symptoms, which at times have been described as menstrual psychoses and could represent an early presentation of Pediatric bipolar disorders. Pediatric bipolar disorders appear to be characterized by less clearly defined mood episodes, shorter duration of these episodes, and different hallmark symptoms than in adults. This report describes a pediatric patient who had no previous psychiatric symptoms and for whom menstrual psychosis was the presenting symptom of bipolar disorder not otherwise specified.
