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1.
J Craniofac Surg ; 31(6): 1551-1555, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32877156

RESUMO

A cleft lip, palate, and alveolus is one of the most common birth defects. Depending on the type of cleft, multiple surgeries may be required throughout the growth stage. Traditionally, an orthodontic-surgical approach has been adopted to treat maxillary retrusion. Osteodistraction it is the surgical choice in patients with severe midface retrusion that require maxillary advancement. Our objective is to present our experience using this orthodontic and surgical approach.


Assuntos
Fenda Labial/cirurgia , Face/cirurgia , Osteogênese por Distração , Alvéolo Dental/cirurgia , Adolescente , Humanos , Masculino , Retrognatismo/cirurgia
2.
Birth Defects Res ; 112(10): 732-739, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32065515

RESUMO

We report the case of a 14-year-old girl that was referred to the maxillo facial surgery unit at age 11 years because she exhibited swelling in the right side of her maxilla and right mandible. After a conservative surgery, she started with interferon alpha-2a to avoid recurrence. She has remained in treatment with successful results during her follow up. Considerable reduction of both maxilla and mandible lesions and bone fill have been documented. In addition, her clinical history and phenotype were suggestive of Noonan syndrome. She has short stature, broad and short neck; hypertelorism (increased distance between the eyes); downslanting palpebral fissures; sparse eyebrows and eyelashes; posteriorly rotated ears with fleshy lobes; follicular keratosis over the face, and developmental delay. Her karyotype was 46, XX. Molecular analysis of RAS/MAPK pathway genes showed a SOS1 amino acid substitution of arginine to lysine at position 552 (p.R552K). This case presents the infrequent condition of Noonan syndrome with multiple giant cell lesions (NS/MGCL) that would be the first patient as far as we know treated with surgery and interferon alpha-2a for her giant cell lesions.


Assuntos
Células Gigantes , Síndrome de Noonan , Adolescente , Substituição de Aminoácidos , Criança , Feminino , Humanos , Interferon-alfa , Síndrome de Noonan/genética , Fenótipo
3.
J Craniofac Surg ; 29(6): 1421-1425, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29916983

RESUMO

: Mandibular reconstruction in pediatric patients is controversial. The scant pediatric experience and the infrequent occurrence of this type of pathology in children complicate therapeutic decisions. The literature contains different treatment protocols and describes the bone graft alternatives to be used. MATERIALS AND METHOD: This is a retrospective review of patients under the age of 15 who were subjected to resection and reconstruction. RESULTS: A total of 18 patients were included in the study: 8 women and 10 men. The age on the date of diagnosis ranged from 2 years to 13 years and the average was 7 years. Five patients underwent resective surgery for a malign pathology, 7 for a benign pathology, 4 for aggressive lesions of odontogenic origin, and 1for the effects of a fracture that was complicated by osteomyelitis. CONCLUSIONS: In conclusion, treating pediatric patients with tumor pathology requires an experience pediatric team to get good outcomes. Surgeons must consider that pediatric patients are in constant growth and development but that must not be an issue in resection and reconstruction decisions. Literature review shows that, as in adults, free flaps seem to be the criterion standard for big resections in mandibles defects, and are safe to use in pediatric patients.


Assuntos
Mandíbula/cirurgia , Reconstrução Mandibular/métodos , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Estudos Retrospectivos
4.
J Oral Maxillofac Surg ; 75(1): 226.e1-226.e7, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27741418

RESUMO

Mandibular tumors are rare in children. Most mandibular tumors in children are benign and locally aggressive, and some might require resection to prevent recurrence. Mandibular reconstruction after tumor resection in children has been less documented in published studies than mandibular reconstruction in adults. In children, age, the growth potential of the mandible, and the donor site are important factors that must be considered. The costochondral graft is an option for reconstruction of the resected portion of the mandible in children, especially when the resection involves the condyle, owing to its biologic and anatomic similarity to the temporomandibular joint and its regenerative and growth potential. The objective of the present case report is to present the unusual remodeling of a nonvascularized costochondral graft after mandibular resection in a pediatric patient.


Assuntos
Transplante Ósseo/métodos , Fibroma Desmoplásico/cirurgia , Neoplasias Mandibulares/cirurgia , Reconstrução Mandibular/métodos , Pré-Escolar , Feminino , Fibroma Desmoplásico/diagnóstico por imagem , Fibroma Desmoplásico/patologia , Humanos , Mandíbula/patologia , Mandíbula/cirurgia , Neoplasias Mandibulares/diagnóstico por imagem , Neoplasias Mandibulares/patologia , Articulação Temporomandibular/cirurgia , Tomografia Computadorizada por Raios X
5.
Rev Chilena Infectol ; 32(4): 458-63, 2015 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-26436794

RESUMO

The fungi of the order Mucorales cause mucormycosis, which usually presents as an invasive fungal disease with rapid angioinvasion in immunocompromised patients. Rhinocerebral is the most common presentation. The lipid formulations of amphotericin B are used as primary treatment in invasive mucormycosis; the combined use of posaconazole could allow a reduction in the dose of amphotericin B improving tolerance and adherence to treatment. Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models. We present the case of a preschool patient that during the debut of acute lymphoblastic leukemia developed a rhinocerebral mucormycosis successfully responding to antifungal treatment with the combination of liposomal amphotericin and caspofungin.


Assuntos
Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Hospedeiro Imunocomprometido , Sinusite Maxilar/terapia , Mucormicose/terapia , Leucemia-Linfoma Linfoblástico de Células Precursoras/microbiologia , Caspofungina , Pré-Escolar , Equinocandinas/uso terapêutico , Feminino , Humanos , Lipopeptídeos , Sinusite Maxilar/microbiologia , Mucormicose/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Tomografia Computadorizada por Raios X , Resultado do Tratamento
6.
Rev. chil. infectol ; 32(4): 458-463, ago. 2015. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-762645

RESUMO

The fungi of the order Mucorales cause mucormycosis, which usually presents as an invasive fungal disease with rapid angioinvasion in immunocompromised patients. Rhinocerebral is the most common presentation. The lipid formulations of amphotericin B are used as primary treatment in invasive mucormycosis; the combined use of posaconazole could allow a reduction in the dose of amphotericin B improving tolerance and adherence to treatment. Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models. We present the case of a preschool patient that during the debut of acute lymphoblastic leukemia developed a rhinocerebral mucormycosis successfully responding to antifungal treatment with the combination of liposomal amphotericin and caspofungin.


Los hongos del orden Mucorales causan la mucormicosis, que se presenta habitualmente como una enfermedad fúngica invasora con rápida angioinvasión en pacientes inmunocomprometidos. La presentación rino-cerebral es la más frecuente. Las formulaciones lipídicas de anfotericina B se usan como tratamiento primario en las mucormicosis invasoras; el uso combinado de posaconazol podría permitir reducir la dosis de anfotericina B generando una mejor tolerancia y adherencia al tratamiento. La asociación de caspofungina con anfotericina ha demostrado acción sinérgica in vitro y eficacia en modelos murinos. Se presenta el caso de una niña preescolar que durante el debut de una leucemia linfoblástica aguda evolucionó con una mucormicosis rino-cerebral persistente, que respondió en forma exitosa al tratamiento antifúngico combinado de anfotericina liposomal y caspofungina.


Assuntos
Pré-Escolar , Feminino , Humanos , Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Hospedeiro Imunocomprometido , Sinusite Maxilar/terapia , Mucormicose/terapia , Leucemia-Linfoma Linfoblástico de Células Precursoras/microbiologia , Equinocandinas/uso terapêutico , Sinusite Maxilar/microbiologia , Mucormicose/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Tomografia Computadorizada por Raios X , Resultado do Tratamento
7.
Anesth Prog ; 55(1): 2-8, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18327969

RESUMO

The aim of this study was to compare the effectiveness of 2 different volumes of anesthetic solution for a premolar-molar extraction, and to determine the onset of complete mandibular conduction anesthesia via a Gow-Gates mandibular block. One operator performed 32 blocks with a 27-gauge needle on patients who required a dental extraction: 16 blocks using 1.8 mL of anesthetic solution, and 16 blocks using 3.6 mL of anesthetic solution. The parameters evaluated were frequency of successful anesthesia and onset of complete anesthesia. Significant differences (P < .005) were observed in the evaluation of volume: the 3.6 mL group yielded a higher success rate (82.5%) than the 1.8 mL group (17.5%). The onset of complete conduction anesthesia was achieved in 8 minutes by 56% of the subjects (9 of 16) with 3.6 mL and only one subject in 16 (6%) with 1.8 mL. A larger volume of anesthetic solution (3.6 mL) is required to achieve a higher success rate and a faster onset of action for a dental extraction without the use of reinforcement anesthesia. The volume of anesthetic solution is indirectly proportional to the onset of complete anesthesia. A premolar-molar extraction can be done, with 3.6 mL of anesthetic solution, in more than 50% of the patients 8 minutes after injection.


Assuntos
Anestesia Dentária/métodos , Anestésicos Locais/administração & dosagem , Nervo Mandibular , Bloqueio Nervoso/métodos , Extração Dentária , Adolescente , Adulto , Idoso , Anestesia Dentária/instrumentação , Dente Pré-Molar/cirurgia , Criança , Feminino , Humanos , Injeções/instrumentação , Nervo Lingual/efeitos dos fármacos , Masculino , Nervo Mandibular/efeitos dos fármacos , Pessoa de Meia-Idade , Dente Molar/cirurgia , Agulhas , Bloqueio Nervoso/instrumentação , Limiar da Dor/efeitos dos fármacos , Projetos Piloto , Fatores de Tempo , Resultado do Tratamento
8.
Rev. dent. Chile ; 88(3): 4-6, nov. 1997. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-216334

RESUMO

Las lesiones a células gigantes son patologias poco frecuentes de los maxilares y el diagnóstico diferencial entre ellas se realiza principalmente por sus características clínicopatológicas y exámenes de laboratorio, ya que sus características histopatológicas son muy similares. En el presente trabajo se hace una revisión estadística de 171 casos de lesiones a células gigantes estudiadas en el IREPO entre los años 1975 y 1996. Se analizan los tratamientos descritos en la literatura y se describen dos casos clínicos de granulomas central tratados en el Servicio de Cirugía Maxilo Facial del Hospital San Juan de Dios, uno con cirugía y el segundo con tratamiento de infiltración


Assuntos
Humanos , Criança , Adulto , Granuloma de Células Gigantes/diagnóstico , Neoplasias Maxilares/diagnóstico , Granuloma de Células Gigantes/terapia , Lidocaína/administração & dosagem , Triancinolona
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