[Bibliometric study of the production and use of the Farmacia Hospitalaria journal (2004-2012)]. / Estudio bibliométrico de producción y consumo de la revista Farmacia Hospitalaria (2004-2012).

OBJECTIVE: To analyze the scientific activity and the production of information of the Farmacia Hospitalaria journal as the Spanish scientific publication of reference in the pharmaceutical area. METHODS: Transversal descriptive study of the results obtained from the bibliometric analysis of the articles published in the journal. Data was obtained from direct queries and Internet access to the scientific literature contained in the electronic version of the journal during the 2004-2012 period. RESULTS: During the period studied 756 articles were published. The number of original articles was 258 (34.12%) with a productivity index of 2.40. The number of institutions identified with published articles was 246. The predominant language was Spanish with 733 (96.96%) articles. We counted 1828 keywords, of which 527 (28.83%) coincided with MeSH. The median calculation of the obsolescence of quoted references was 10, and the Price Index was 8.81%. The percentage of selfquotes was 5.18%. CONCLUSIONS: We confirmed a low proportion of original articles and an adequate percentage of satisfactory quotable articles. The low percentage of keywords that coincide with Medical Subject Headings is noteworthy. The bibliographical references found in the articles come mainly from the English-speaking area and from journals indexed in the Journal Citation Report. The obsolescence analysis of these references produced high results.

Estudio bibliométrico de producción y consumo de la revista Farmacia Hospitalaria (2004-2012) / Bibliometric study of the production and use of the Farmacia Hospitalaria journal (2004-2012)

Objetivo: Analizar la actividad científica y la producción de información de la revista Farmacia Hospitalaria como publicación científica española de referencia en el área de la farmacia. Método: Estudio descriptivo transversal de los resultados obtenidos del análisis bibliométrico de los artículos publicados en la revista, obteniéndose los datos de la consulta directa y acceso, vía Internet, a la literatura científica recogida en la versión electrónica de la revista en el periodo 2004 a 2012.Resultados: Durante el periodo estudiado se publicaron 756artículos. El número de originales fue de 258 (34,13%), siendo el índice de productividad de 2,40. Se identificaron 246 instituciones con trabajos publicados. El idioma predominante fue el español con 733 (96,96%) artículos. Se contabilizaron 1828palabras clave, de las cuales 527 (28,83%) se correspondían con MeSH. La obsolescencia de las referencias citadas, medida por la mediana es de 10 y el Índice de Price es del 8,81%. El porcentaje de autocitas fue del 5,18%.Conclusiones: Se comprobó baja proporción de artículos originales y adecuado porcentaje de artículos citables adecuados. Es reseñable el bajo porcentaje de Palabras clave que coinciden con los Medical Subject Headings. Las referencias bibliográficas recogidas en sus artículos proceden mayoritariamente del ámbito anglófono y de revistas indizadas en la Journal Citation Report. El análisis de la obsolescencia de estas referencias dio resultados elevados

Objective: To analyze the scientific activity and the production of information of the Farmacia Hospitalaria journal as the Spanish scientific publication of reference in the pharmaceutical area. Methods: Transversal descriptive study of the results obtained from the bibliometric analysis of the articles published in the journal. Data was obtained from direct querys and Internet access to the scientific literature contained in the electronic version of the journal during the 2004-2012 period. Results: During the period studied 756 articles were published. The number of original articles was 258 (34.12%) with a productivity index of 2.40. The number of institutions identified with published articles was 246. The predominant language was Spanish with 733 (96.96%) articles. We counted 1828 key key-words, of which 527 (28.83%) coincided with MeSH. Themedian calculation of the obsolescence of quoted referenceswas 10, and the Price Index was 8.81%. The percentage of self-quotes was 5.18%. Conclusions: We confirmed a low proportion of original articlesand an adequate percentage of satisfactory quotable articles.The low percentage of keywords that coincide with MedicalSubject Headings is noteworthy. The bibliographical referencesfound in the articles come mainy from the English-speaking areaand from journals indexed in the Journal Citation Report. Theobsolescence analysis of these references produced high results

Visibilidad de la producción científica iberoamericana en nutrición: la importancia de las palabras clave / Visibility of the Latin-American scientific production on nutrition: The importance of the key words

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[Bibliometric study of the Journal Nutrición Hospitalaria for the period 2001-2005: Part 1, Analysis of the scientific production]. / Estudio bibliométrico de la revista Nutrición Hospitalaria en el periodo 2001 a 2005: Parte I, Análisis de la producción científica.

OBJECTIVE: To assess the scientific activity and information production of the journal Nutrición Hospitalaria, for the period 2001-2005 by means of a Bibliometric study. METHOD: Cross-sectional descriptive study of the results obtained from the analysis of the articles published in the journal Nutrición Hospitalaria. The data were obtained by consulting the electronic version through the Web. In those cases in which there was a link breakdown, and thus, the inability to have access to the electronic document the printed version was consulted. All the documental possibilities were taken into account with the exception of communications to congresses. RESULTS: A total of 345 articles were published, 187 (54.20%) being original articles. The geographical distribution of the first author was Spanish in 287 articles (83.19%) and Latin American in 27 (7.83%). Most of the articles are from health care centers (172 articles (49.86%)), and the cooperation index being 4.15. Madrid is the most productive province, for both the absolute and adjusted frequencies. The median number of references per article is 18, the mean being 23.52 (95% CI 20.93 - 26.10). The predominant language was Spanish, with 308 articles (89.28%). CONCLUSION: Nutrición Hospitalaria may be considered as a reference journal regarding information and scientific communication on Nutrition for both the Spanish and Latin American communities. The bibliometric parameters studied compare with those verified for the remaining top of the list Spanish scientific journals on health sciences.

[Bibliometric study of the journal Nutrición Hospitalaria for the period 2001--2005: Part 2, consumption analysis; the bibliographic references]. / Estudio bibliométrico de la revista Nutrición Hospitalaria en el periodo 2001 a 2005: parte 2, análisis de consumo; las referencias bibliográficas.

OBJECTIVE: To describe and assess the consumption of the information consulted and cited in the articles published in the journal Nutrición Hospitalaria for the period 2001--2005 by means of bibliometric analysis. METHOD: Cross-sectional descriptive analysis of the results obtained from the analysis of the lists of bibliographic references of the articles published at Nutrición Hospitalaria. We studied the most cited journals, the signatures index, the type of document referred, the publication language, the distribution of geographical origin, and obsolescence and readiness index. We took into account all types of documents with the exception of Communications to Congresses. RESULTS: 345 articles were published at Nutr Hosp, containing 8,113 bibliographic references, with a median of 18, a maximum of 136 and minimum of 0 BR per article. The mean (rate of publications per published article during the specified period) is 23.52 (95% IC 20.93-26.10) and the mean at 5% is 20.66 per article. The 25th and 75th percentiles are 6 and 32, respectively, the interquartile interval being 26 BR per document. The semi-period of Burton and Kebler is 7 years and the Price Index is 38.18%. CONCLUSION: The bibliographic references, the consumption of information, of the articles published at Nutrición Hospitalaria present parameters similar to other journals on health science. However, good data on obsolescence are observed, which reveal the good validity of most of the references studied.

Systemic allergy to human insulin and its rapid and long acting analogs: successful treatment by continuous subcutaneous insulin lispro infusion.

Since the introduction of highly purified human recombinant insulin, allergy to insulin has become a very rare clinical situation, encountered in less than 1% of patients. It results in potentially life-threatening immediate or delayed, local and general manifestations. Different treatments of unequal efficiency have been proposed, the use of insulin analogs showing benefits in certain situations. We report the case of a type 2 diabetic patient who presented local reactions and then an anaphylactic shock after the introduction of insulin analog premixes. Intra-dermal reactions performed with porcine, human and insulin analogs preparations (aspart, lispro, glargine) were all positive, as well as the specific anti-insulin IgE measurement. Because we could not achieve normoglycaemia with maximal oral treatment and low caloric diet, we decided to attempt a desensitisation by continuous subcutaneous infusion of insulin lispro, since the lowest skin reaction was obtained with this insulin. We were able to induce a tolerance, by means of very low basal rate, very slowly increased, without any boluses, and maintaining antihistamine therapy. Six months later, the patient remains free of any symptom and has achieved a quite good glycaemic control. We describe for the first time a case of allergy to human insulin and to all available rapid and long acting analogs. We show the interest of a treatment with CSII of analogs in order to induce tolerance.

Kelley-Seegmiller syndrome due to a new variant of the hypoxanthine-guanine phosphoribosyltransferase (I136T) encoding gene (HPRT Marseille).

A patient with hyperuricaemia and gouty arthritis due to a new variant of hypoxanthine-guanine phosphoribosyltransferase is described. The mutation (I136T, HPRT Marseille) is in the phosphoribosylpyrophosphate-binding region of the gene and leads to almost total loss of enzyme activity in erythrocytes, with 5% in lymphocytes. Nevertheless, the patient showed no neurological abnormality.