On-site testing and treatment of sexually transmitted infections among female sex workers using molecular point-of-care testing integrated into harm reduction services in Madrid, Spain.

INTRODUCTION: This study aimed to evaluate the feasibility of molecular point-of-care testing for STIs, the prevalence of STIs and associated factors, and testing and treatment uptake among street-based female sex workers (FSWs) attending a mobile harm reduction unit in Madrid, Spain. METHODS: This was a prospective, longitudinal study. From August 15th to December 6th, 2022, participants were screened for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis using molecular testing (Xpert) on self-collected urine samples at a mobile harm reduction unit. Additionally, rapid tests were used to screen participants for HIV, hepatitis C virus (HCV), and syphilis. On-site same-day results and treatment for those infected were offered. RESULTS: Among 77 FSWs included the median age was 40 (range, 33-48), 64 % were homeless, and 84 % reported drug use in the past six months. Four participants self-reported having HIV, of whom all were on antiretroviral therapy, and 14 (18 %) had HCV antibodies, including three with current infection. The prevalence of at least one STI was 66 %. When categorized by type of STI, the prevalences were as follows: 15 % for CT, 15 % for NG, 51 % for TV, and 21 % for syphilis. Notably, the prevalence of STIs was higher among FSW with recent drug use, with no cases of CT or NG detected among FSWs who did not recently use drugs. In adjusted analysis, drug use was associated an increased odds of having an STI (adjusted odds ratio, 10.47; 95 % CI: 1.67-65.42). All participants consented to screening, and all but one received on-site result-based linkage to treatment. CONCLUSIONS: This study demonstrates the feasibility, high STI prevalence, and high linkage to testing and treatment following point-of-care molecular testing among street-based FSWs who have recently used drugs in Madrid, Spain.

Satisfaction and medication adherence in women with vulvovaginal atrophy: the CRETA.

OBJECTIVE: This study aimed to evaluate the self-reported satisfaction of Spanish postmenopausal women currently treated for vulvovaginal atrophy (VVA) symptoms. METHODS: The CRETA (CRoss sectional European sTudy on Adherence) is a multicenter cross-sectional study conducted in 29 public and private hospitals in Spain, which enrolled postmenopausal women receiving treatment with ospemifene, local hormone therapy (HT) or vaginal moisturizers for VVA. After the prior informed consent of the patients, sociodemographic and treatment perception data were collected using a structured questionnaire. RESULTS: Among 752 women who completed the survey, the satisfaction score was significantly higher for the group treated with ospemifene (mean 8.3 ± 1.4) compared with the local HT group (7.2 ± 1.7) and the vaginal moisturizer group (6.5 ± 2.1) according to a 10-point Likert scale (p < 0.0001). Compared to vaginal moisturizers and local HT, participants treated with ospemifene reported the highest adherence (96.7% vs. 70.2% and 78.6%, respectively) and the lowest number of missed doses in the last month (0.6 ± 1.3 standard deviation [SD] vs. 3.5 ± 4.3 SD and 2.0 ± 2.8 SD, respectively) (p < 0.0001). Ospemifene was significantly perceived as easy to use (83.9% vs. 44.9% and 58.6%, respectively; p < 0.0001), efficacious in reducing the time to relieve symptoms (17.1% vs. 7.0% and 6.7%, p = 0.0005 and p = 0.0006, respectively) and convenient for sexual life (53.1% vs. 25.6% and 42.3%, p < 0.0001 and p = 0.0234, respectively). CONCLUSIONS: Among postmenopausal women with VVA, treatment with ospemifene has the most positive perceptions and the highest overall satisfaction level and could be an optimal therapeutic approach, maximizing patient adherence.

Search for Gamma-Ray Spectral Lines from Dark Matter Annihilation up to 100 TeV toward the Galactic Center with MAGIC.

Linelike features in TeV γ rays constitute a "smoking gun" for TeV-scale particle dark matter and new physics. Probing the Galactic Center region with ground-based Cherenkov telescopes enables the search for TeV spectral features in immediate association with a dense dark matter reservoir at a sensitivity out of reach for satellite γ-ray detectors, and direct detection and collider experiments. We report on 223 hours of observations of the Galactic Center region with the MAGIC stereoscopic telescope system reaching γ-ray energies up to 100 TeV. We improved the sensitivity to spectral lines at high energies using large-zenith-angle observations and a novel background modeling method within a maximum-likelihood analysis in the energy domain. No linelike spectral feature is found in our analysis. Therefore, we constrain the cross section for dark matter annihilation into two photons to ⟨σv⟩≲5×10^{-28} cm^{3} s^{-1} at 1 TeV and ⟨σv⟩≲1×10^{-25} cm^{3} s^{-1} at 100 TeV, achieving the best limits to date for a dark matter mass above 20 TeV and a cuspy dark matter profile at the Galactic Center. Finally, we use the derived limits for both cuspy and cored dark matter profiles to constrain supersymmetric wino models.

Mass transfer enhancement and improved nitrification in MABR through specific membrane configuration.

One of the main energy consumptions in wastewater treatment plants (WWTPs) is due to the oxygenation of aerobic biological processes. In order to approach to an energy self-sufficient scenario in WWTPs, Membrane Aerated Biofilm Reactors (MABRs) provide a good opportunity to reduce the impact of aeration on the global energy balance. However, mass transfer limitations derived from poor flow distribution must be tackled to take advantage of this technology. In this work, in order to improve mass transfer between biofilm and bulk water, a specific configuration was developed and studied at laboratory scale, aimed at compactness, energy efficiency and high nitrification rates. Nitrification rates were higher in the innovative configuration than in the conventional one, achieving a Volumetric Nitrification Rate (VNR) as high as 575.84 g NH4-N m-3 d-1, which is comparable with confirmed technologies. Regarding energy consumption due to aeration, a reduction of 83.7% was reached in comparison with aeration through diffusers with the same Oxygen Transfer Efficiency (OTE). These results highlight the importance of hydrodynamic conditions and the membranes configuration on treatment performance.

Isolation of the symbiotic fungus of Acromyrmex pubescens and phylogeny of Leucoagaricus gongylophorus from leaf-cutting ants.

Leaf-cutting ants live in an obligate symbiosis with a Leucoagaricus species, a basidiomycete that serves as a food source to the larvae and queen. The aim of this work was to isolate, identify and complete the phylogenetic study of Leucoagaricus gongylophorus species of Acromyrmex pubescens. Macroscopic and microscopic features were used to identify the fungal symbiont of the ants. The ITS1-5.8S-ITS2 region was used as molecular marker for the molecular identification and to evaluate the phylogeny within the Leucoagaricus genus. One fungal symbiont associated with A. pubescens was isolated and identified as L. gongylophorus. The phylogeny of Leucoagaricus obtained using the ITS molecular marker revealed three well established monophyletic groups. It was possible to recognize one clade of Leucoagaricus associated with phylogenetically derived leaf-cutting ants (Acromyrmex and Atta). A second clade of free living forms of Leucoagaricus (non-cultivated), and a third clade of Leucoagaricus associated with phylogenetically basal genera of ants were also recognized. The clades corresponded to traditional taxonomic groups, and were differentiated by ecological habitats of different species.

Effects of dilution rate and water reuse on biomass and lipid production of Scenedesmus obliquus in a two-stage novel photobioreactor.

Continuous culture of fresh water microalgae Scenedesmus obliquus was developed in a two-stage photobioreactor, avoiding the intermediate harvesting step to achieve a half-way point between the progressive and the sudden N-starvation strategies, guaranteeing light limited conditions in the first stage and N-stress conditions in the second stage. This methodology resulted in biomass productivity values at the best dilution rate (0.118 days(-1)) of 15.25±1.06 g m(-2) d(-1), slightly higher than that expected according to batch experiment (12.90±0.75 g m(-2) d(-1)). The dilution rate that maximized the lipid content was coincident with that for the maximum biomass productivity, resulting in a intensification of the lipid productivity. Microalgae can be successfully cultured in reused medium clarified by high pH flocculation-sedimentation and neutralized by bubbling the photobioreactors outlet CO2 current through it. Microalgae flocculation with NaOH does not result in a variation of the obtained lipid profile.

High pH-induced flocculation-sedimentation and effect of supernatant reuse on growth rate and lipid productivity of Scenedesmus obliquus and Chlorella vulgaris.

High pH-induced flocculation-sedimentation of Scenedesmus obliquus and Chlorella vulgaris was studied with the objective of improving the efficiency of microalgae harvesting, since it is one of the most expensive steps of production of microalgae. Desired pH values were achieved by addition of NaOH and Ca(OH)(2). Growth rate and lipid productivity in fresh media prepared with tap water and with analytical-grade water, and in reused media prepared with culture centrifuged supernatant and the supernatant from high pH-induced flocculation-sedimentation were compared. Since the growth rates for reused media were about 1.7 times higher than in fresh media, and the lipid productivities were about 25 and 26 mg L(-1) d(-1) in flocculated and centrifuged reused media respectively, medium reuse is a suitable method of saving water and nutrients.

Especies de Candida en pacientes VIH/SIDA con candidiasis orofaringea / Candida species in HIV/AIDS patients with oropharygeal candidiasis

La infección por Candida a nivel orofaríngeo, es la infección oportunista más frecuente en pacientes VIH/SIDA,al menos un episodio de candidiasis desarrollan estos pacientes en el curso de la evolución de su enfermedad. La determinación de especies de Candida, permite orientar de manera adecuada el tratamiento. El objetivo de la presente investigación fue identificar las especies de Candida aisladas en 60 pacientes VIH/SIDA con candidiasis orofaríngea, asistentes al Centro de Atención Integral - Enfermedades de Transmisión sexual y SIDA. (CAI/ETS/SIDA) en el período Junio-Diciembre 2006. Se les tomó muestra de raspado lingual y se cultivó en Agar Sabouraud-Cloranfenicol para el aislamiento primario. La identificación de las especies de Candida, se realizó por medio de la producción de: tubos germinativos, clamidosporas en Agar - Maiz Tween 80 según la técnica de Dalmau y el sistema Api 20CAUX bioMérieux. Se observó en estos pacientes predominio del sexo masculino (48) 80%, con edades comprendidas entre 20 y 60 años Se aislaron en orden de frecuencia C. albicans 66,6 % (40), C. tropicalis 13,33 % (8), C. glabrata 11,6 % (7), C. parapsilosis 6,66 % (4), C. krusei, 66% (1). Se recomienda la identificación de especies de Candida como prueba de rutina en pacientes VIH/SIDA

Oral candidiasis has been recognized as the most common opportunistic infection in HIV/AIDS patients. These patients present at least one episode of oral candidiasis in the development of the disease. The isolation of Candida species has let to apply the correct treatment to these patients. The purpose of the investigation was to identify the species of isolated Candida in 60 HIV/AIDS patients with oropharyngeal candidiasis that assist to the Center of Integral Attention of Sexual Transmission Diseases and AIDS from June to December 2006. The samples were taken from the mucosal surface of the tongue and laid in Sabouraud-Cloramphenicol agar for the first isolation; the identification of Candida species were done by forming germ tubes, Terminal Chlamydospore formation on corn meal agar with Tween-80 following the Dalmau technique and the Api 20CAUX bioMerieux. Most of the patients were males (48) 80% and age ranging 20 to 60 years old. The most frequent yeast specie found was : C, albicans 66,6 % (40) , C. tropicalis 13,33 % (8) , C. glabrata 11,6 % (7) ,C. parapsilosis 6,66 % (4) , C. krusei 1,66% (1). It is recommended the isolation of the species as a rutin test in the HIV/AIDS patients

Metabolic syndrome in HIV-infected patients receiving antiretroviral therapy in Latin America.

OBJECTIVE: To evaluate the prevalence of and the associated factors for metabolic syndrome (MS) among Latin American HIV-infected patients receiving antiretroviral therapy (ART) using baseline data from the RAPID II study. METHODS: A longitudinal study to evaluate the metabolic profile, cardiovascular disease (CVD) risk and associated treatment practices to reduce this risk has been conducted in seven Latin American countries (the RAPID II study). Adult HIV patients with at least six months of RT were enrolled. MS was defined following ATP-III criteria. Demographic and anthropometric data, serum biochemical and clinical parameters were compared in patients with and without MS using bivariate and multivariate analysis. RESULTS: A total of 4,010 patients were enrolled, 2,963 (74%) were males. Mean age (SD) was 41.9 (10.0) years. The prevalence of MS was 20.2%. Females had higher prevalence of MS than males (22.7% vs. 19.4%, p = 0.02). MS was driven by high triglycerides, low HDL-cholesterol and high blood pressure (HBP). Patients with MS had higher 10 year CVD risk: 22.2% vs. 7.4%, p < 0.001. Age (OR: 1.05 per year), female gender (OR: 1.29), family history of CVD (OR: 1.28), CD4 cell count (OR: 1.09 per 100 cell increase), and protease inhibitor based-ART (OR: 1.33) correlated with MS in the multivariate analysis. CONCLUSIONS: Prevalence of MS in this setting was similar to that reported from developed countries. MS was driven by high triglycerides, low-HDL and HBP, and it was associated with higher risk of CVD. Traditional risk factors, female gender, immune reconstitution, and protease inhibitor based-ART correlated with MS.

Metabolic syndrome in HIV-infected patients receiving antiretroviral therapy in Latin America

OBJECTIVE: To evaluate the prevalence of and the associated factors for metabolic syndrome (MS) among Latin American HIV-infected patients receiving antiretroviral therapy (ART) using baseline data from the RAPID II study. METHODS: A longitudinal study to evaluate the metabolic profile, cardiovascular disease (CVD) risk and associated treatment practices to reduce this risk has been conducted in seven Latin American countries (the RAPID II study). Adult HIV patients with at least six months of RT were enrolled. MS was defined following ATP-III criteria. Demographic and anthropometric data, serum biochemical and clinical parameters were compared in patients with and without MS using bivariate and multivariate analysis. RESULTS: A total of 4,010 patients were enrolled, 2,963 (74 percent) were males. Mean age (SD) was 41.9 (10.0) years. The prevalence of MS was 20.2 percent. Females had higher prevalence of MS than males (22.7 percent vs. 19.4 percent, p = 0.02). MS was driven by high triglycerides, low HDL-cholesterol and high blood pressure (HBP). Patients with MS had higher 10year CVD risk: 22.2 percent vs. 7.4 percent, p < 0.001. Age (OR: 1.05 per year), female gender (OR: 1.29), family history of CVD (OR: 1.28), CD4 cell count (OR: 1.09 per 100 cell increase), and protease inhibitor based-ART (OR: 1.33) correlated with MS in the multivariate analysis. CONCLUSIONS: Prevalence of MS in this setting was similar to that reported from developed countries. MS was driven by high triglycerides, low-HDL and HBP, and it was associated with higher risk of CVD. Traditional risk factors, female gender, immune reconstitution, and protease inhibitor based-ART correlated with MS.

Ulcus vulvae acutum / Ulcus vulvae acutum

El ulcus vulvae acutum es una úlcera en vulva de diagnóstico infrecuente que suele aparecer en mujeres adolescentes sin relación con enfermedad venérea. Las úlceras son grandes, múltiples y dolorosas asociándose a fiebre muy alta. Curan espontáneamente, pero el clínico debe hacer un buen diagnóstico diferencial para evitar un sobrediagnóstico de enfermedades ulcerativas más frecuentes, corno el herpes genital, con peor pronóstico evolutivo para la paciente

Ulcus vulvae acutum is a rare diagnosis with fever, ulceration of extemal genital organs and lymphadenomegaly most often seen in adolescent girls without venereal infection. The sloughy ulcers are often multiple. They heal spontaneously but this rare disease is usually misdiagnosed by specialists and is a diagnosis to considerer when herpes simplex, which is the most common cause for genital ulceration, is not the cause

Specific leaf mass, fresh: dry weight ratio, sugar and protein contnts in species of Lamiaceae from different light enviroments

Samples from eleven species of Lamiaceae were collected from different light environments in Venezuela for laboratory analysis.The studied species were: Plectranthus scutellarioides (Ps), Scutellaria purpurascens (Sp), Hyptis pectinata (Hp), H. sinuata (Hs), Leonorus japonicus (Lj), Plecthranthus amboinicus (Pa) Ocimum basilicum (Ocb), O.campechianum (Occ) Origanum majorana (Orm), Rosmarinus officinali ,(Ro) and Salvia officinalis (So). Protein and soluble sugar contents per unit of area were measured, Specific Leaf Mass (SLM)and fresh: dry weight (FW/DW) ratios were calculated. The higher values for soluble sugars contents were present in sun species: Lj, Pa, Ocb, Occ, Or. m, Ro and So; the lower values were obtained in low light species: Ps, Sp, Hp, Hs. The values of protein content do not show any clear trend or difference between sun and shade environments. The lowest values for the fresh weight: dry weight ratio are observed in sun species with the exception of Lj and Pa, while the highest value is observed in Pa, a succulent plant. The higher values of specific leaf mass (SLM)(Kg DMm-2) are observed in sun plants. The two way ANOVA revealed that there were significant differences among species and between sun and low light environments for sugar content and FW: DW ratio, while SLM was significant for environments but no significant for species, and not significant for protein for both species and environments. The soluble sugar content, FW: DW ratio and SLM values obtained in this work, show a clear separation between sun and shade plants. The sugar content and FW:DW ratio are distinctive within the species,and the light environment affected sugar content, FW:DW ratio and SLM. These species may be shade-tolerant and able to survive in sunny environments. Perhaps these species originated in shaded environments and have been adapting to sunny habitats

En once especies de la familia Lamiaceae: Plecthranthus scutellarioides R. Br. (Ps); S cutellaria purpurascens Sw.(Sp); Hyptis pectinata (L.) Poit.(Hp); Hyptis sinuata Kunth (Hs); Ocimum basilicum L.(Ocb); Ocimum campechianum Miller.(Occ); Origanum majorana L.(Orm); Rosmarinus officinalis L.(Ro); Salvia officinalis L.(So) and Plecthranthus amboinicus (Lour) Spreng.(Pa) and Leonorus japonicus Hout., (Lj), provenientes de diferentes ambientes de exposición a la luz solar, fueron medidos los contenidos de proteínas y azúcares, expresados por unidad de área y fueron calculados la masa específica foliar (MEF)y la relación peso fresco: peso seco (PF:PS). Los mayores valores en el contenido de azúcar fueron observados en plantas que crecieron a exposición directa de luz solar: Lj, Pa, Ocb, Occ, Or. m, Ro and So; mientras que los menores valores se presentaron en aquellas plantas provenientes de ambientes más frecuentemente sombreados e interrumpidos por rayos de sol: Ps, Sp, Hp, Hs. Los valores en el contenido de proteínas no muestran diferencias. Los menores valores de PF:DW fueron observados en las plantas expuestas a radiación solar directa, con la excepción de L. japonicus y P. amboinicus ,esta última es suculenta. Los mayores valores de MEF se presentaron en plantas de sol. El análisis de varianza de dos vías reveló que había diferencias significativas entre especies y ambientes para el contenido de azúcares y la relación PF: PS, mientras que para MEF, la diferencia fue significativa solo entre ambientes; en el caso del contenido de proteínas las diferencias no fueron significativas para especies y ambientes. El contenido de azúcares, la relación PF: PS y la MEF muestran una clara separación entre las especies de sol y las de sombra. Parece que en las especies de Lamiaceae estudiadas, el contenido de azúcares, y la relación PF: PS son distintivos entre las especies mismas y la radiación solar afecta el contenido de azúcares, la relación PF: PS y la MEF. Podría suponerse que estas especies sean tolerantes a la sombra y capaces a su vez, de vivir en ambientes soleados, más aún, de acuerdo a estos resultados y a otros relativos a estas mismas especies, pudiera interpretarse que tienen su origen en ambientes sombreados y que han ido ocupando y adaptándose a ambientes soleados, basándose en la plasticidad fisiológica inducida por las variaciones ambientales de luz

Specific leaf mass, fresh: dry weight ratio, sugar and protein contents in species of Lamiaceae from different light environments.

Samples from eleven species of Lamiaceae were collected from different light environments in Venezuela for laboratory analysis. The studied species were: Plectranthus scutellarioides (Ps), Scutellaria purpurascens (Sp), Hyptis pectinata (Hp)), H. sinuata (Hs). Leonorus japonicus (Lj), Plecthranthus amboinicus (Pa) Ocimum hasilicum (Ocb), O. campechianum (Occ) Origanum majorana (Orm), Rosmarinus officinali, (Ro) and Salvia officinalis (So). Protein and soluble sugar contents per unit of area were measured, Specific Leaf Mass (SLM) and fresh:dry weight (FW/DW) ratios were calculated. The higher values for soluble sugars contents were present in sun species: Lj, Pa, Ocb, Occ, Orm, Ro and So; the lower values were obtained in low light species: Ps, Sp, Hp, Hs. The values of protein content do not show any clear trend or difference between sun and shade environments. The lowest values for the fresh weight: dry weight ratio are observed in sun species with the exception of Lj and Pa, while the highest value is observed in Pa, a succulent plant. The higher values of specific leaf mass (SLM) (Kg DMm(-2)) are observed in sun plants. The two way ANOVA revealed that there were significant differences among species and between sun and low light environments for sugar content and FW:DW ratio. while SLM was significant for environments but no significant for species, and not significant for protein for both species and environments. The soluble sugar content, FW:DW ratio and SLM values obtained in this work, show a clear separation between sun and shade plants. The sugar content and FW:DW ratio are distinctive within the species, and the light environment affected sugar content. FW:DW ratio and SLM. These species may he shade-tolerant and able to survive in sunny environments. Perhaps these species originated in shaded environments and have been adapting to sunny habitats.

Intoxicación por metanol / Methanol poisoning

La intoxicación por metanol es poco frecuente pero de una gran morbimortalidad. Suele ocurrir accidentalmente al manipular productos industriales como anticongelantes o disolventes. En España la forma de intoxicación más habitual es el intento autolítico. Presentamos dos casos fatales que presentaban coma y acidosis metabólica importante (pH < 7) al ingreso. En ambos casos la sospecha diagnóstica fue tardía y en ningún caso se instauró tratamiento específico.Queremos destacar la importancia de sospechar de forma precoz esta intoxicación ante un cuadro de coma con acidosis metabólica importante. Parece aceptado que la toxicidad del metanol depende de sus metabolitos. Con frecuencia, los intoxicados presentan síntomas de embriaguez antes de presentar síntomas atribuibles a los metabolitos. Además, el tiempo de latencia hasta la aparición de los síntomas que aparece en la bibliografía oscila entre una y 72 h. Esto hace pensar que puede existir una toxicidad temprana atribuible al metanol per se (AU)

Sensibilidad de listeria monocytogenes frente al fosfato trisódico in vitro / Sensitivity of Listeria monocytogenes to trisodium fosfate in vitro

La carne de pollo presenta un elevado grado de contaminación superficial con microorganismos patógenos para el hombre y alterantes. Con el objeto de reducir dicha contaminación, desde 1992, el fosfato trisódico dodecahidrato (Na3PO4.12H2O) se está empleando en los mataderos de aves de Estados Unidos como un procedimiento de descontaminación. El efecto antimicrobiano de esta sal ha sido sobradamente demostrado frente a algunos microorganismos (fundamentalmente Gram negativos). No obstante, los datos publicados hasta el momento no son concluyentes por lo que se refiere a L. monocytogenes. Este estudio se llevó a cabo para evaluar la sensibilidad de 21 cepas de L. monocytogenes frente al fosfato trisódico in vitro. Para estandarizar la sensibilidad frente al fosfato trisódico utilizamos la concentración mínima inhibitoria, que se consideró como la menor concentración de la sal con la que la absorbancia (al cabo de 24 horas de incubación) no superó el valor 'umbral', que fue definido como el valor medio de las absorbancias de los blancos más tres desviaciones estándar. Los valores de las concentraciones mínimas inhibitorias (1,58-1,68 por ciento) fueron muy similares para las cepas de L. monocytogenes estudiadas. No encontramos ninguna relación entre el valor de la concentración mínima inhibitoria y la procedencia de las cepas (AU)

Planta de desulfurizacion y reformacion catalitica

Contenido: 1ra parte.Proyecto de Planta Desulfurizadora y reformacioncatalitica.Generalidades.Introduccion.Analisis de los compuestos de Azufre.Procesos.Desulfurizacion en fase liquida.Lavado con soluciones alcalinas.Proceso Mercapsol.Proceso solutizer.Tratamiento con sulfurico.Condiciones de tratamiento.Proceso Gray.-Proceso de desulfurizacion catalitica.Periodo de proceso.Preparacion de la gasolina antes de la desulfurizacion y reformacion.Metodos analiticos.Determinacion del carbon depositado en el catalizador..2da parte.Calculos.Descripcion.-Magnitud.-Nomenclatura de simbolos.Fraccionamiento de crudos Sanandita en Laboratorio.Resumen de rendimientos.Anexos.