RESUMO
A platform-tolerant RFID (Radio-Frequency Identification) tag is presented, designed to operate across the entire RFID band. This tag utilizes a small Artificial Magnetic Conductor (AMC) structure as a shielding element for an ungrounded RFID tag antenna. It can be easily mounted on various surfaces, including low permittivity dielectric materials, metal objects, or even attached to the human body for wearable applications. The key features of this RFID tag include its ability to be tuned within the worldwide RFID band, achieving a maximum theoretical read range of over 11 m. Despite its advanced capabilities, the design emphasizes simplicity and cost-effective manufacturing. The design and simulations were conducted using CST Studio Suite.
RESUMO
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These substances were characterized for their capacity to inhibit cyclooxygenase (COX-1 and COX-2) isoenzymes. Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms. The N-arylindole 33 was the most potent inhibitor of COX-2 and also the most selective (COX-1/COX-2 IC(50) ratio was 262). The indole derivative 33 was further tested in vivo for its anti-inflammatory activity in rats. This compound showed greater inhibitory activity than ibuprofen. Other compounds (20, 26, 9, and 30) showed strong activity against carrageenan-induced inflammation. The latter compounds showed a weak capacity to inhibit the proliferation of human cell lines K562, NCI-H460, and HT-29 in vitro.
