1.
J Nucleic Acids
; 2012: 215876, 2012.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23150809
RESUMO
We describe a rational approach devoted to modulate the sugar-phosphate backbone geometry of nucleic acids. Constraints were generated by connecting one oxygen of the phosphate group to a carbon of the sugar moiety. The so-called dioxaphosphorinane rings were introduced at key positions along the sugar-phosphate backbone allowing the control of the six-torsion angles α to ζ defining the polymer structure. The syntheses of all the members of the D-CNA family are described, and we emphasize the effect on secondary structure stabilization of a couple of diastereoisomers of α,ß-D-CNA exhibiting wether B-type canonical values or not.
2.
J Pediatr Gastroenterol Nutr
; 44(2): 283-6, 2007 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17255847