RESUMO
PurposeThe aim of this report is to increase awareness of a possible association between cranial nerve paresis and the use of sumatriptan in migraine sufferers, particularly in patients who have additional vascular risk factors.Patients and methodsWe describe a series of three cases where third nerve paresis developed in patients who were treated with the oral form of sumatriptan. All of the patients had a clear history of repetitive migraine headache and none of them had previous third nerve paresis.ConclusionAmong a variety of medications for the treatment of migraine, there are some drugs with vasoconstrictive effects, particularly triptans. These drugs may be a contributing factor for microvascular damage of the cranial nerves and other organs.
Assuntos
Doenças do Nervo Oculomotor/induzido quimicamente , Paresia/induzido quimicamente , Sumatriptana/efeitos adversos , Vasoconstritores/efeitos adversos , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos de Enxaqueca/tratamento farmacológico , Adulto JovemAssuntos
Anti-Hipertensivos/efeitos adversos , Glaucoma de Ângulo Aberto/tratamento farmacológico , Granuloma/induzido quimicamente , Quinoxalinas/efeitos adversos , Uveíte Anterior/induzido quimicamente , Administração Tópica , Idoso , Tartarato de Brimonidina , Feminino , Humanos , Quinoxalinas/administração & dosagemRESUMO
PURPOSE: To identify any consistent factors which may predict over- or undercorrection of congenital blepharoptosis treated by anterior levator resection. METHODS: A retrospective case note review of 100 consecutive patients undergoing anterior levator resection for congenital blepharoptosis was performed to identify: (1) the amount of ptosis and degree of levator function present pre-operatively and (2) the surgical outcome. For unilateral ptosis, a successful result was defined as a lid level within 1 mm of the fellow lid following a single operation. RESULTS: Seventy-six per cent of all unilateral cases had a successful outcome at 6 weeks following surgery, falling slightly to 74% by 6 months. The most common complications at 6 months were undercorrection (19%) and overcorrection (7%). All patients undercorrected at 6 months had a pre-operative levator function in the range of 4-10 mm with a mean of 6.4 mm, whereas all those overcorrected at 6 months had a levator function in the range 9-15 mm with a mean of 12.2 mm. In the whole population, the degree of levator function was a predictor of increased risk of overcorrection, with a trend towards predicting undercorrection as well. CONCLUSIONS: In this series of patients, pre-operative levator function was found to be the most significant predictor of surgical outcome for anterior levator resection.
Assuntos
Blefaroplastia/métodos , Blefaroptose/congênito , Blefaroptose/cirurgia , Músculos Faciais/cirurgia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: To evaluate the use of the MTI photoscreener (Medical Technology Inc, Iowa City, Iowa) in assessing and documenting lens abnormalities in the pediatric ophthalmology clinic. METHODS: MTI photoscreener photographs of pediatric patients with lens abnormalities were taken to assess and document lens opacities and subluxation, to assist with explanations to parents, and to monitor progression of abnormalities. Postoperative photographs were taken to assess opacification of the posterior capsule and contact lens fit. RESULTS: Nineteen children with lens abnormalities were examined. Twelve patients underwent surgery and 9 patients had postoperative photoscreener pictures. Illustrative cases are reported. CONCLUSION: The MTI photoscreener is a useful adjunct to clinical examination in the assessment and documentation of pediatric lens abnormalities.
Assuntos
Catarata/diagnóstico , Subluxação do Cristalino/diagnóstico , Cristalino/anormalidades , Fotografação/métodos , Afacia Pós-Catarata/reabilitação , Catarata/congênito , Extração de Catarata , Pré-Escolar , Lentes de Contato , Progressão da Doença , Feminino , Humanos , Lactente , Recém-Nascido , Subluxação do Cristalino/etiologia , Subluxação do Cristalino/cirurgia , Masculino , Prognóstico , Estudos RetrospectivosAssuntos
Esotropia/cirurgia , Exotropia/etiologia , Músculos Oculomotores/patologia , Complicações Pós-Operatórias , Hemorragia Retrobulbar/etiologia , Acomodação Ocular , Pré-Escolar , Humanos , Masculino , Músculos Oculomotores/cirurgia , Dor Pós-Operatória/etiologia , Complicações Pós-Operatórias/diagnóstico , Hemorragia Retrobulbar/diagnósticoRESUMO
Uveitis-glaucoma-hyphaema (UGH) syndrome is an unusual cause of transient monocular visual loss which may follow cataract extraction and intraocular lens implantation. If misdiagnosed as amaurosis fugax, patients may undergo unnecessary investigations and inappropriate treatment with aspirin.
Assuntos
Cegueira/etiologia , Glaucoma/etiologia , Hifema/etiologia , Lentes Intraoculares , Complicações Pós-Operatórias/etiologia , Uveíte Anterior/etiologia , Idoso , Cegueira/diagnóstico , Diagnóstico Diferencial , Glaucoma/diagnóstico , Humanos , Hifema/diagnóstico , Ataque Isquêmico Transitório/diagnóstico , Masculino , Complicações Pós-Operatórias/diagnóstico , Síndrome , Uveíte Anterior/diagnósticoRESUMO
Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were farnesylated in vitro by mammalian farnesyl:protein transferase, and epitope-tagged PTP(CAAX2) was prenylated in epithelial cells. Overexpression of PTP(CAAXI) and PTP(CAAX2) in epithelial cells caused a transformed phenotype in culture and tumor growth in nude mice. Thus, PTP(CAAXI) and PTP(CAAX2) represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases.
