1.
Chem Commun (Camb)
; 51(61): 12301-4, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26137967
RESUMO
Solution-phase synthesis of linear and cyclic ß- and α,ß-peptoids was coupled to photo-induced thiol-ene coupling reaction to readily access multivalent thioglycoclusters. A tetrameric cyclic ß-peptoid scaffold displaying 1-thio-ß-d-galactose or 1-thio-α-d-mannose has revealed by ITC experiments efficient binding potency for bacterial lectins LecA and BC2L-A, respectively.
Assuntos
Burkholderia cenocepacia/química , Química Click , Lectinas/química , Peptoides/síntese química , Pseudomonas aeruginosa/química , Compostos de Sulfidrila/síntese química , Estrutura Molecular , Peptoides/química , Processos Fotoquímicos , Compostos de Sulfidrila/química
2.
Org Lett
; 15(9): 2246-9, 2013 May 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23590358
RESUMO
The very simple sterically hindered tert-butyl side chain exerts complete control over the peptoid amide geometry which only exists in the cis conformation. It is exemplified in NtBu glycine homo-oligomers and in linear oligopeptoids designed with an alternating cis-trans backbone amide pattern.