RESUMO
Among 54 consecutive patients with acute nonseptic embolic brain infarction, there was CT evidence of hemorrhagic infarction in 1 patient (2%). None had clinical or CT evidence of massive brain hemorrhage even when anticoagulation therapy was used immediately. Seven patients (13%) had recurrent brain emboli, all within 7 days of the initial stroke. None of these patients was adequately anticoagulated at the time of recurrence. Immediate anticoagulation therapy should be employed after nonseptic embolic brain infarction if CT does not show hemorrhage and there is a persistent cardiac source of emboli.
Assuntos
Hemorragia Cerebral/induzido quimicamente , Infarto Cerebral/tratamento farmacológico , Heparina/uso terapêutico , Embolia e Trombose Intracraniana/tratamento farmacológico , Varfarina/uso terapêutico , Feminino , Cardiopatias/complicações , Heparina/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Tomografia Computadorizada por Raios X , Varfarina/efeitos adversosRESUMO
Neuropathologic changes in patients with cystic fibrosis include dystrophic axons in the nucleus gracilis and demyelination of the fasciculus gracilis. We reviewed 43 autopsy cases of cystic fibrosis to determine the incidence and severity of these changes. Sixty-six percent of patients developed dystrophic axons. There was a direct correlation between severity of neuroaxonal dystrophy and duration of disease. Demyelination of the fasciculus gracilis occurred in 11%. The neuropathology of cystic fibrosis resembles that of vitamin E deficiency in animals. However, vitamin E replacement failed to prevent neuropathologic changes in these patients.
