RESUMO
A simple method is presented for estimating a non-lethal level for inhalation toxicity studies. By reviewing 209 LC(50) studies representing 96 chemicals that also reported a non-lethal level, it has been shown that taking 1/3 of the LC(50) is a conservative estimate for a non-lethal exposure level. This approach was also compared to studies with LC(01) and BMCL(05) calculations. In the 38 studies that reported either of these values, again taking 1/3 of the LC(50) provided a more conservation estimate for the non-lethal threshold. The studies included time intervals from 5min out to 8h and utilized multiple species such as the rat, mouse, hamster, guinea pig and dog. In all but 13 cases, taking 1/3 of the LC(50) provided a more conservative estimate for a non-lethal exposure level compared to the experimentally observed value. In all but one of the 13 cases, the higher values were consequences of the selection of the exposure levels.
Assuntos
Poluentes Atmosféricos/toxicidade , Animais , Relação Dose-Resposta a Droga , Exposição por Inalação , Dose Letal Mediana , Nível de Efeito Adverso não Observado , Medição de RiscoRESUMO
Emergency Response Planning Guidelines (ERPGs) are airborne concentrations of chemicals that have been evaluated for three levels of emergency response. These are a nuisance level, and level that would affect egress from an exposure or a level that is near, but below a life threatening concentration. The ERPG is a volunteer committee of the American Industrial Hygiene Association that is comprised of industrial hygienists and toxicologists. This paper describes the history of emergency response guidelines and process of the evaluation.
