[Importance of the time for stopping the combined use of aspirin and clopidogrel in patients undergoing coronary artery by-pass graft surgery]. / Importancia del tiempo de suspensión del uso combinado de aspirina y clopidogrel en pacientes sometidos a cirugía de revascularización coronaria.

The combined use of aspirin and clopidogrel is the standard of care for patients with acute coronary syndromes. The risk for perioperative bleeding is considerably increased after coronary artery by-pass graft surgery (CABG). This study was designed to evaluate the effect of antiplatelet therapy on perioperative CABG outcome. We studied 49 consecutive patients undergoing first time CABG, and compared two groups: Group A, patients who stopped antiplatelet treatment at least 6 days before surgery, and group B, those who received antiplatelet therapy within 5 days before surgery or did not suspended therapy. The groups were comparable in their demographic characteristics, manifestations of disease, perioperative medication use and the characteristics of surgery. There was a non significant tendency for more cardiovascular complications (primary cardiovascular endpoint) in the group that stopped antiplatelet therapy 6 or more days before surgery (Group A 12%, group B 8%; p = 0.923). The bleeding endpoint was significantly higher in group B, that remained on antiplatelet therapy within 5 days before surgery (Group A 4%, group B 29%; p = 0.023), as well as the need for transfusion. We concluded that the combined use of aspirin and clopidogrel before CABG increases postoperative bleeding and morbidity; there was no definitive difference in the cardiovascular outcome.

Importancia del tiempo de suspensión del uso combinado de aspirina y clopidogrel en pacientes sometidos a cirugía de revascularización coronaria / Importance of the time for stopping the combined use of aspirin and clopidogrel in patients undergoing coronary artery by-pass graft surgery

The combined use of aspirin and clopidogrel is the standard of care for patients with acute coronary syndromes. The risk for perioperative bleeding is considerably increased after coronary artery by-pass graft surgery (CABG). This study was designed to evaluate the effect of antiplatelet therapy on perioperative CABG outcome. We studied 49 consecutive patients undergoing first time CABG, and compared two groups: Group A, patients who stopped antiplatelet treatment at least 6 days before surgery, and group B, those who received antiplatelet therapy within 5 days before surgery or did not suspended therapy. The groups were comparable in their demographic characteristics, manifestations of disease, perioperative medication use and the characteristics of surgery. There was a non significant tendency for more cardiovascular complications (primary cardiovascular endpoint) in the group that stopped antiplatelet therapy 6 or more days before surgery (Group A 12%, group B 8%; p = 0.923). The bleeding endpoint was significantly higher in group B, that remained on antiplatelet therapy within 5 days before surgery (Group A 4%, group B 29%; p = 0.023), as well as the need for transfusion. We concluded that the combined use of aspirin and clopidogrel before CABG increases postoperative bleeding and morbidity; there was no definitive difference in the cardiovascular outcome.

[Reconstruction of the normal right ventricle outflow tract in the Ross operation]. / Reconstrucción del tracto de salida normal del ventrículo derecho en la operación de Ross.

Now a day there are many surgical procedures that require intervention on the normal right ventricular outflow tract (RVOT) and its reconstruction. We present the surgical anatomy of the pulmonary root in the normal RVOT and its reconstruction in the Ross operation in 13 patients operated on from February 1992 through February 1994. The surgical excision of the pulmonary valve was done and in order to keep right ventricle-pulmonary artery continuity (RV-PA), autologous pericardium tubes with bovine pericardium valve [done at the Instituto Nacional de Cardiología (INC)], were elaborated during the surgical procedure in all patients. The postoperative period and its clinical status was satisfactory in all cases, without transpulmonary gradient or regurgitation. We conclude that is important to know the surgical anatomy of the pulmonary root in order to avoid irreversible damage. In the other hand, it is worthy to know the different choices to reconstruct RVOT and its postoperative clinical course.

[Mitral valve replacement by mechanical disk valve. A surgical alternative]. / Substitución valvular mitral con prótesis mecánica de disco. Una alternativa quirúrgica.

From July to December 1993, 10 patients underwent mitral valve replacement with mechanical disc valve and running suture, preserving the posterior mitral valve apparatus. There were 6 men and 4 women, with a mean age of 44.2 years (25 to 63 years old). Three patients were in functional class II of the NYHA, 5 in functional class III and 2 in functional class IV. Eight patients were operated on for simple mitral valve replacement, of which, 2 underwent the first replacement 4 the second replacement and 2 the third replacement. One patient underwent double valve replacement (mitral and aortic valves) plus "bicuspidization" of the tricuspid valve and one patient underwent myocardial revascularization with two grafts of reverse saphenous vein besides mitral valve replacement. We used cardiopulmonary bypass in all patients with moderate hypothermia at 28 degrees and cardiac protection with cold cardioplegia at 4 degrees with potassium. One to 2 dosis of cardioplegia were required. Aortic cross clamping time was 37 minutes and 64 minutes of cardiopulmonary bypass in the patients operated on of simple mitral valve replacement. Supported by these preliminary results, we conclude that this surgical alternative is effective and safe with less ischemic and cardiopulmonary bypass time, preserve the posterior mitral apparatus and avoid disc jamming by the residual leaflet or tendinous chordae.

[Intraoperative circulatory collapse due to a coronary spasm following successful coronary revascularization]. / Colapso circulatorio intraoperatorio debido a espasmo coronario después de revascularización coronaria exitosa.

Coronary artery spasm is recognized cause of angina and circulatory collapse during the operative and early postoperative period following cardiopulmonary bypass for coronary artery surgery. We present our experience with hemodynamical collapse during cardiopulmonary bypass weaning, which were refractory to treatment with inotropics such as noradrenaline and adrenalin and vasodilators such as nitroglycerin. The electrocardiographic changes, poor answer to medical treatment following successful cardiopulmonary bypass for coronary artery surgery, good myocardial protection and complete revascularization suggested severe coronary artery spasm. We used sublingual nifedipine, achieving hemodynamical stability and stopping inotropic support and cardiopulmonary bypass. We review the literature about pathophysiologic mechanism and treatment of coronary artery spasm.

[Pulmonary valve autograft for aortic valvulopathy]. / Autotrasplante de la válvula pulmonar para valvulopatía aórtica.

Twelve patients were operated on between February 1992 and June 1993 because aortic valve disease with pulmonary autograft replacement of the aortic valve and reconstruction of the right ventricular outflow tract with a valved tube of autogenous pericardium and bovine prosthetic pericardium valve made at the Instituto Nacional de Cardiología Ignacio Chávez. Aortic and pulmonary annular diameters were taken preoperative in all patients by transthoracic echocardiography. During the surgical procedure, transthoracic echocardiography was done in order to assess valvular function of the pulmonary autograft. There was no peri-operative morbi-mortality and no anticoagulation was required. Post operative evolution was satisfactory in all patients and were discharged after transthoracic echocardiography evaluation. Annular diameters correlated with the trans-surgical annular measurements. We conclude that the use of the pulmonary autograft in selected cases can be done, in order to relieve aortic valve disease, without significant morbi-mortality as compared with single aortic valve replacement.

[Pericardiectomy: a challenge, a reality. The surgical experience of the Instituto Nacional de Cardiología "Ignacio Chávez"]. / Pericardiectomía "un reto, una realidad". Experiencia quirúrgica del Instituto Nacional de Cardiología "Ignacio Chávez".

The surgical aspect of the pericardial disease has grown in the last years due to new diagnostic, surgical and anesthetic procedures. We reviewed 20 patients, who underwent pericardiectomy in the National Institute of Cardiology "Ignacio Chávez" between august 1987 and september 1992. Nine males and eleven females whose age ranged from 18 years to 57 years with a mean of 35.8 years. We found as causes of pericardial disease: 5 patients with recurrent pericardial effusion, 4 constrictive pericarditis, 2 cases with uremic pericarditis, 2 cases of "postpericardiotomy syndrome" 2 cases of infectious origin, idiopathic causes in two, others less frequent causes were neoplastic pericarditis in one, post-traumatic in one and secondary to radiotherapy in another one. The diagnosis was made by clinical findings, chest X rays, echocardiography and cardiac catheterization. A medial sternotomy was made in all patients, and the pericardium resection was made toward the anterior aspect of the phrenic nerve. In all the patients operative monitoring included central venous catheter and radial indwelling catheter, Swan Ganz catheter in 12 cases (60%) and cardiopulmonary bypass available. One death was reported in an uremic patient, secondary to low cardiac output and multiple organic failure. One year mortality increased to 10% with the inclusion of a rhabdomyosarcoma. Surgical complications included two cases (10%) with supraventricular arrhythmias, one case (5%) incomplete right bundle branch block, postoperative bleeding one (5%) and other one (5%) postoperative mediastinitis.(ABSTRACT TRUNCATED AT 250 WORDS)