RESUMO
The intraocular penetration of Ciprofloxacin in man: authors have studied the penetration of Ciprofloxacin in the aqueous humor of 30 patients (30 eyes). The concentration in the anterior chamber was on average 0.73 mg/l which is 33% of serum level, from 1.30 hours after a single oral dose of 1000 mg till the 4th hour after this dose. The samples were assessed by a microbiological method. These results are over the minimal inhibitory concentration for many bacterial agents found in endophthalmitis. So this antibiotic may be proposed in the treatment of endophthalmitis. Anyway further investigation is mandatory to assess the safety on efficacy of these antibiotics.
Assuntos
Humor Aquoso/química , Ciprofloxacina/farmacocinética , Administração Oral , Idoso , Idoso de 80 Anos ou mais , Ciprofloxacina/administração & dosagem , Ciprofloxacina/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In our daily clinical practice, keratomycosis still remain a challenge for both the ophthalmologist and the laboratory. In this paper simple advices are listed to help us, especially in the topical medical treatment. The emerging role of silver sulfadiazine is pointed out.
Assuntos
Antifúngicos/uso terapêutico , Doenças da Córnea/tratamento farmacológico , Micoses/tratamento farmacológico , Doenças da Córnea/parasitologia , Doenças da Córnea/prevenção & controle , Humanos , Micoses/prevenção & controleRESUMO
Authors have studied the penetration of ciprofloxacin in the aqueous humor of 30 patients (30 eyes). The concentration in the anterior chamber was on average 0.73 mg/l (33% of serum level), from 1.30 hours after a single oral dose (1000 mg) till the 5th hour after this dose. The samples were assessed by a microbiological method. These results are over the minimal inhibitory concentration for many bacterial agents found in endophthalmitis. So this antibiotic may be proposed in the treatment of endophthalmitis, with further investigations assessing the safety of this procedure.
Assuntos
Humor Aquoso/análise , Ciprofloxacina/farmacocinética , Idoso , Idoso de 80 Anos ou mais , Humor Aquoso/metabolismo , Infecções Bacterianas/tratamento farmacológico , Catarata/tratamento farmacológico , Extração de Catarata , Ciprofloxacina/análise , Ciprofloxacina/uso terapêutico , Oftalmopatias/tratamento farmacológico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pré-MedicaçãoRESUMO
Choroid osteoma was described for the first time by GASS in 1978. Today only 53 cases were reported in 39 patients. Using 3 new cases recently discovered in our region, we try to assess with the help of the already published data, the main points of the disease and its diagnostic.