RESUMO
We investigated the activity of endogenous nucleoside 5'-deoxy-5'-methylthioadenosine (MTA) on both the production of inflammatory cytokines and the cytokine-dependent endothelial expression of adhesion molecules. The compound inhibited the production of tumor necrosis factor (but not interleukin-1) in lipopolysaccharide-activated macrophages. In addition, MTA selectively inhibited the expression of intercellular adhesion molecule-1 in endothelial cells activated with interleukin-1. This effect was paralleled by a reduction in endothelial adhesiveness for polymorphonuclear leukocytes. These data suggest that MTA might have anti-inflammatory activity.
Assuntos
Moléculas de Adesão Celular/biossíntese , Citocininas/biossíntese , Desoxiadenosinas/farmacologia , Endotélio Vascular/imunologia , Tionucleosídeos/farmacologia , Animais , Adesão Celular/imunologia , Moléculas de Adesão Celular/imunologia , Citocininas/antagonistas & inibidores , Ensaio de Imunoadsorção Enzimática , Feminino , Técnicas In Vitro , Macrófagos/efeitos dos fármacos , Macrófagos/imunologia , Camundongos , Camundongos Endogâmicos C57BL , Neutrófilos/efeitos dos fármacos , Neutrófilos/imunologia , Fator de Necrose Tumoral alfa/biossínteseAssuntos
Cefotaxima/uso terapêutico , Pneumonia/tratamento farmacológico , Adolescente , Cefotaxima/efeitos adversos , Criança , Pré-Escolar , Infecções por Haemophilus/tratamento farmacológico , Haemophilus influenzae , Humanos , Lactente , Recém-Nascido , Pneumonia/etiologia , Pneumonia Pneumocócica/tratamento farmacológico , Infecções Estreptocócicas/tratamento farmacológico , Streptococcus pyogenesRESUMO
Transient hyperphosphatasemia of infancy is a biochemical syndrome characterized by a striking, transient increase in serum alkaline phosphatase in children without any evidence of bone or liver disease and of a familial occurrence. The abnormal isoenzyme pattern frequently observed in this syndrome may represent an excessively sialylated form of the liver isoenzyme, not normally removed from circulation. Here are described four new cases of this syndrome, followed biochemically and clinically until normalization of the serum abnormalities; a review of literature is also presented.