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Abstract Introduction Factors affecting the quality of physician care include a shortage of trained staff, stigma, and discrimination. Objective The objective was to compare the intensity of stigmatization before and after a Psychiatry course, as measured by the scale of clinicians' attitudes towards mental illness, a version for medical students (MICA-2) designed to identify stigmatic attitudes towards mental disorders. Method The fifth-year Medicine students enrolled in the Psychiatry course answered anonymously using the MICA-2 test at the start and the end of their course. Additionally, we asked the students to answer a question about their interest in learning more about mental illness. Results Three hundred and thirty students were invited; 300 agreed to participate in the first application of the scales, and 291 in the follow-up. The average age was 22 ± 2 years, with a range of 20-30 years, and there was a similar gender distribution in both applications. In the initial application, the average score of the MICA-2 was 41.34 (SD = 7.86, 95% CI = [40.43, 42.25]). The follow-up application's mean was 37.10 (SD = 8.15, 95% CI = [36.30, 38.15]). Also, there was a decrease in interest in learning more about mental illness. Discussion and conclusion A reduction in the average scores of the MICA-2 was observed after a Psychiatry course, suggesting that attitudes toward mental disorders improved. A Psychiatry clerkship with close supervision modified the attitudes of medical students toward mental disorders. However, it did not increase their interest in learning more about mental illness.
Resumen Introducción Los factores que afectan la calidad de la atención médica incluyen: la escasez de personal capacitado, el estigma y la discriminación. Objetivo El objetivo fue comparar la intensidad de la estigmatización antes y después del curso de Psiquiatría, se utilizó la escala de las actitudes de los clínicos hacia la enfermedad mental, versión para estudiantes médicos (MICA-2), diseñada para identificar actitudes estigmatizantes hacia los trastornos mentales. Método Los estudiantes médicos de quinto año que tomaban el curso de Psiquiatría respondieron de forma anónima la escala MICA-2 al inicio y al final del curso. Además, se les preguntó sobre su interés en aprender más sobre los trastornos mentales. Resultados Se invitaron a 330 estudiantes; 300 aceptaron participar en la primera aplicación de las escalas y 291 en el seguimiento. La edad promedio fue de 22 ± 2 años, con un rango de 20-30 años; con una distribución de género similar en ambas aplicaciones. En la aplicación inicial, la puntuación media del MICA-2 fue de 41.34 (DE = 7.86, IC 95% = [40.43, 42.25]). En la de seguimiento, la media fue de 37.10 (DE = 8.15, IC 95% = [36.30, 38.15]). El interés en aprender más sobre los trastornos mentales disminuyó. Discusión y conclusión Observamos una reducción en los puntajes promedio después de tomar el curso de Psiquiatría, lo que sugiere que las actitudes hacia los trastornos mentales mejoraron. Un curso de Psiquiatría con mayor disposición y supervisión estrecha modificó las actitudes hacia los trastornos mentales de los estudiantes médicos, pero su interés en aprender más sobre los trastornos mentales disminuyó.
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The use of biomimetic models of the glomerulus has the potential to improve our understanding of the pathogenesis of kidney diseases and to enable progress in therapeutics. Current in vitro models comprise organ-on-a-chip, scaffold-based and organoid approaches. Glomerulus-on-a-chip designs mimic components of glomerular microfluidic flow but lack the inherent complexity of the glomerular filtration barrier. Scaffold-based 3D culture systems and organoids provide greater microenvironmental complexity but do not replicate fluid flows and dynamic responses to fluidic stimuli. As the available models do not accurately model the structure or filtration function of the glomerulus, their applications are limited. An optimal approach to glomerular modelling is yet to be developed, but the field will probably benefit from advances in biofabrication techniques. In particular, 3D bioprinting technologies could enable the fabrication of constructs that recapitulate the complex structure of the glomerulus and the glomerular filtration barrier. The next generation of in vitro glomerular models must be suitable for high(er)-content or/and high(er)-throughput screening to enable continuous and systematic monitoring. Moreover, coupling of glomerular or kidney models with those of other organs is a promising approach to enable modelling of partial or full-body responses to drugs and prediction of therapeutic outcomes.
