Improved post-marketing safety surveillance of quadrivalent inactivated influenza vaccine in Mexico using a computerized, SMS-based follow-up system.

Quadrivalent influenza vaccines (QIVs) are designed to prevent influenza disease caused by two influenza A viruses (H1N1 and H3N2) and both influenza B lineages. Risk-monitoring of QIVs to identify adverse events (AEs) is necessary as influenza vaccines are reformulated each year. We developed a new active surveillance system (Sistema de Control de Vacunación; SICOVA) to improve pharmacovigilance in Mexico. Participants (N = 2013) aged 0 - 96 years from nine sites across three influenza seasons (n = 1166 in 2015 - 2016; n = 633 in 2016 - 2017; and n = 214 in 2017 - 2018) agreed to receive text messages 1, 7, 28, and 42 days post-vaccination to know if they had experienced any AEs. The study was completed electronically by 1763 (87.6%) participants; manual follow-up was conducted for 250 participants whose reporting was incomplete. The overall AE rate was 9.09%. At least one AE was reported by 183 participants, of whom 131 (71.58%) did not require a medical visit and 52 (28.42%) needed medical attention, with none requiring hospitalization. Most AEs requiring medical attention occurred in children aged 0 - 5 years (n = 22, 42.31%) and adults aged 31 - 35 years (n = 5, 9.62%). These results are consistent with the established safety profile of Fluzone® Quadrivalent, and show that SICOVA can facilitate surveillance and increase AE reporting in Mexico.

Intention to accept Bordetella pertussis booster vaccine during pregnancy in Mexico City.

OBJECTIVE: Adult booster vaccination against pertussis can help prevent severe infections in young infants. We examined influences on intention to accept pertussis booster vaccination among pregnant women in Mexico City. METHODS: We conducted a cross-sectional survey, recruiting convenience samples of pregnant women receiving prenatal care from three public healthcare centers between March and May 2012. Our primary outcome was intention to accept pertussis vaccination during pregnancy. We examined socio-demographic factors, vaccination history, pertussis knowledge, perceptions of vaccine information sources, and other potential influences on vaccine decision-making. RESULTS: A total of 402 pregnant women agreed to participate, of which 387 (96%) provided their intention to accept or decline pertussis vaccination. Among respondents, 57% intended to accept a pertussis booster vaccine if offered, but only 16% had ever heard of pertussis, and only 2% knew someone who had contracted this disease. Over 80% of respondents would accept pertussis vaccination if recommended by an obstetrician-gynecologist. The most frequently selected reasons to refuse pertussis vaccination were concerns that the vaccine might harm the unborn baby or pregnant woman. In multivariate analysis, rating doctors and nurses as good sources of vaccine information, and having ever heard of pertussis, were independently associated with intention to accept pertussis vaccination. CONCLUSIONS: Promoting patient awareness about pertussis disease and vaccine safety, and encouraging general practitioners, nurses and obstetricians to recommend pertussis booster vaccine, may increase vaccine uptake among pregnant women.

Complicaciones neurológicas del síndrome de nevo epidérmico: presentación de un caso / Neurological complications of epidermal nevus syndrome

Introducción. El síndrome de nevo epidérmico se caracteriza por presentarse concomitantemente con alteraciones en otros sistemas, en particular sistema nervioso central por lo que es considerado como uno de los síndromes neurocutáneos. Caso clínico. Se presenta el caso de paciente femenino de 3 meses de edad con manifestaciones de síndrome de nevo epidérmico y neurológicas caracterizadas por crisis epilépticas parciales motoras de hemicuerpo izquierdo, secundariamente generalizadas, retardo en el desarrollo psicomotor, asociado con alteraciones sistémicas diversas como quiste dérmico parietal derecho, poliotia izquierda, entropión derecho, microcórnea, opacidad bilateral del cristalino, paladar hendido, hernia umbilidal e inguinal izquierda, cursó en la etapa de recién nacido con quilotórax y colestasis hepática, presentando al nacimiento dermatosis en hemicuerpo derecho de características verrugosas e hiperpigmentadas. Conclusión. El caso es de interés por su variedad de manifestaciones clínicas, asociado con paladar hendido y quilotórax no reportado en la literatura revisada. Podría tratarse de otro síndrome o ser una variante poco común, meritoria de ofrecer consejo genético a pesar de ser de presentación esporádica