Assuntos
Pseudomonas aeruginosa/patogenicidade , Antibacterianos/farmacologia , Proteínas de Bactérias/metabolismo , Toxinas Bacterianas/metabolismo , Movimento Celular , Resistência Microbiana a Medicamentos , Proteínas Hemolisinas/metabolismo , Pseudomonas aeruginosa/efeitos dos fármacos , Pseudomonas aeruginosa/metabolismo , VirulênciaRESUMO
Susceptibility to inorganic mercuric ions and to organomercurials of 237 Pseudomonas aeruginosa clinical strains isolated in Mexico was determined by agar dilution tests. Resistant strains fell into two classes: i) narrow-spectrum resistant strains (27% of total isolates) resistant only to mercuric ions and to merbromin, and most grouped in pyocin type 1; and ii) broad-spectrum resistant strains (5%) with additional resistances to thimerosal, phenylmercury, methylmercury and p-hydroxymercuribenzoate, that belonged mostly to pyocin type 10. Mercurial resistant isolates showed a higher proportion of resistance to antibiotics and metals than did mercurial sensitive isolates, and broad-spectrum resistant strains had the highest frequency of resistance to antibiotics and to tellurite and arsenate.
Assuntos
Mercúrio/farmacologia , Pseudomonas aeruginosa/efeitos dos fármacos , Humanos , Hidroximercuribenzoatos/farmacologia , Merbromina/farmacologia , Cloreto de Mercúrio/farmacologia , Compostos de Metilmercúrio/farmacologia , Acetato de Fenilmercúrio/farmacologia , Timerosal/farmacologiaAssuntos
Bacteriocinas/análise , Pseudomonas aeruginosa/classificação , Piocinas/análise , Antibacterianos/farmacologia , Infecção Hospitalar/microbiologia , Resistência Microbiana a Medicamentos , Humanos , México , Infecções por Pseudomonas/microbiologia , Pseudomonas aeruginosa/efeitos dos fármacosRESUMO
Three hundred and twenty two clinical isolates of Pseudomonas aeruginosa collected in Morelia, México, were analyzed for in vitro susceptibility to five antibiotics by agar dilution tests. Antibiotic resistance was shown by 50% of total isolates. Frequencies of resistance were: streptomycin, 47%; gentamicin, 13%; tobramycin, 8%; and carbenicillin, 7%; no amikacin resistance was found. The more common resistance patterns were streptomycin, gentamicin-streptomycin, and tobramycin-gentamicin-streptomycin. Resistance to either tobramycin, gentamicin or carbenicillin was found mainly in pyocin type 10 isolates. The proportion of antibiotic resistant isolates ranged from 37 to 75% in four hospitals, and amounted 24% in three clinical laboratories.
Assuntos
Antibacterianos/farmacologia , Pseudomonas aeruginosa/efeitos dos fármacos , Resistência Microbiana a Medicamentos , Humanos , Testes de Sensibilidade Microbiana/métodos , Pseudomonas aeruginosa/isolamento & purificaçãoRESUMO
The susceptibility of 326 clinical isolates of Pseudomonas aeruginosa to four metals was determined by agar dilution tests. Metal resistance was shown by 36% of the total isolates. The frequencies of resistance to individual ions were: mercuric, 31%; tellurite, 12%; arsenate, 10%; and chromate, 3%. The most frequent pattern was that of resistance to mercuric ions alone followed by mercury resistance associated with either tellurite, arsenate, or both. Resistance to more than one metal was found in 44% of metal-resistant isolates. The resistance to antibiotics was more frequent among metal-resistant isolates that in metal-sensitive isolates.
