RESUMO
In this study, a number of novel 5-aryl-2-[(N,N-disubstituted thiocarbamoylthio)acylamino]-1,3,4-oxadiazole derivatives were synthesized by the reaction of potassium salts of N,N-disubstituted dithiocarbamoic acids with 2-[(alpha-chloro-alpha-phenylacetyl/alpha-bromopropionyl)-amino]-5 -aryl-1, 3,4-oxadiazoles. Structures of the compounds were confirmed by the spectral data (IR, 1H NMR, EIMS) and elemental analyses. Most of the compounds were tested against various microorganisms and four of them were found to be weakly active against Staphylococcus aureus and Staphylococcus epidermidis.
Assuntos
Antibacterianos/síntese química , Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Oxidiazóis/síntese química , Oxidiazóis/farmacologia , Antibacterianos/química , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Testes de Sensibilidade Microbiana , Estrutura Molecular , Oxidiazóis/química , Espectrofotometria InfravermelhoRESUMO
The synthesis of 12 new 4-[(N,N-disubstituted thiocarbamoylthio)acetamido]antipyrines and their antifungal activity are reported. Of these compounds, only 3e, showed good antifungal activity against C. tropicalis KUEN 1021, C. krusei KUEN 1001, C. stellatoidea KUEN 1018, C. pseudotropicalis KUEN 1012, C. albicans ATCC 10231 when compared with clotrimazole and miconazole (MIC = 12.5 micrograms/ml).
Assuntos
Antifúngicos/farmacologia , Antipirina/farmacologia , Antifúngicos/síntese química , Antipirina/análogos & derivados , Antipirina/síntese química , Estrutura MolecularRESUMO
Several 2-[(2-methylimidazo[1,2-a]pyridine-3-yl)carbonyl]hydrazono- 3-nonsubstituted/substituted-4-phenyl-4-thiazolines (3a-d, 3f-h) and 3-(2-methylimidazo[1,2-a]pyridine-3-yl)-4-nonsubstituted/substitut ed-5- mercapto-4H-1,2,4-triazoles (4a-f, 4i) were synthesized, characterized and evaluated for anticonvulsant activity. Only 3g showed significant activity against MES induced seizures.
