1.
Bioorg Med Chem Lett
; 20(7): 2344-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20189807
RESUMO
From potent and selective inhibitors of GSK3beta displaying CYP1A2 inhibition and poor PK properties, mostly linked to metabolic instability and in vivo hydrolysis of the amide bond, we were able to obtain safe and orally available inhibitors with good half lives.