[Membrane-active preparations as correctors of the nephrotoxicity of gentamicin]. / Membranoaktivnye preparaty kak korrektory nefrotoksichnosti gentamitsina.

At intracutaneous gentamicine injections in rats (dose 50 mg/kg) within 10 days the simultaneous application of anticalcium drugs makes nephrotoxic signs more pronounced; whereas antioxidants and essenciale make them less pronounced. Phospholipid complex, containing phosphatidylserin, sphingomyelin, and phosphatidylethanolamine does not exhibit a marked nephroprotective effect. The found character of changes in content of phosphoinozytols in urine indirectly confirms the role of disturbances of their metabolism in mechanism of aminoglycoside nephrotoxicity.