RESUMO
Pancreatic pseudocyst-portal vein fistulae are a very rare complication of acute or chronic pancreatitis. Another late complication of chronic pancreatitis is pancreatic ascites. We report the case of a 43-year-old man with a spontaneous pseudocyst-portal vein fistula presenting with pancreatic ascites diagnosed by various imaging modalities, in order to emphasize the strength and efficacy of magnetic resonance cholangiopancreatography.
Assuntos
Ascite/diagnóstico , Fístula Pancreática/diagnóstico , Pseudocisto Pancreático/diagnóstico , Veia Porta , Fístula Vascular/diagnóstico , Adulto , Ascite/etiologia , Colangiopancreatografia Retrógrada Endoscópica , Colangiopancreatografia por Ressonância Magnética , Humanos , Masculino , Pseudocisto Pancreático/complicações , Pancreatite Alcoólica/complicações , Tomografia Computadorizada por Raios X , Fístula Vascular/complicaçõesRESUMO
Although it has been well known that the role of LPS on hepatotoxicity is mediated through TNF-alpha, the direct cytotoxic effect of LPS on IFN-gamma-primed hepatocytes has not yet been clearly demonstrated. Here, we demonstrate that the IFN-gamma-mediated death of murine embryonic liver BNL CL2 cells is potentiated by LPS (0.5 microg/ml). In addition, an exogenous NO donor, sodium nitroprusside (SNP) significantly prevents cell death induced by IFN-gamma alone or IFN-gamma plus LPS (IFN-gamma/LPS) in a dose-dependent manner over 25 microM. SNP significantly blocked the death of BNL CL2 cells only when it was added within 12 hr after treatment of IFN-gamma and IFN-gamma/LPS. The preventive effect of SNP occurred in parallel with the suppression of caspase 3-like protease activation. We have also demonstrated that a relatively high concentration as well as an appropriate period of exposure to NO may be critical to maintain cell viability from the cytotoxic effect of IFN-gamma and IFN-gamma/LPS. Furthermore, the preventive effect of SNP on IFN-gamma/LPS-induced cell death is mediated by a protein kinase G (PKG)-independent manner.
Assuntos
Hepatócitos/efeitos dos fármacos , Interferon gama/toxicidade , Lipopolissacarídeos/toxicidade , Óxido Nítrico/fisiologia , Animais , Caspase 3 , Caspases/metabolismo , Morte Celular/efeitos dos fármacos , Morte Celular/fisiologia , Linhagem Celular , GMP Cíclico/metabolismo , Proteínas Quinases Dependentes de GMP Cíclico/metabolismo , Ativação Enzimática/efeitos dos fármacos , Hepatócitos/patologia , Hepatócitos/fisiologia , Camundongos , Óxido Nítrico/biossíntese , Doadores de Óxido Nítrico/farmacologia , Nitroprussiato/farmacologia , Proteínas RecombinantesRESUMO
WHIM syndrome is a rare congenital familial syndrome consisting of warts, hypogammaglobulinemia, infections, and myelokathexis. We describe a 30-year-old man with WHIM syndrome, in whom red dermal facial nodules developed. The diagnosis of B-cell lymphoma was established with biopsy and immunohistochemical studies. To our knowledge, this is the first reported case of WHIM syndrome complicated by a B-cell lymphoma.
Assuntos
Agamaglobulinemia/complicações , Linfoma de Células B/complicações , Neoplasias Cutâneas/complicações , Verrugas/complicações , Adulto , Humanos , Infecções/complicações , Masculino , SíndromeAssuntos
Imunoglobulinas Intravenosas/uso terapêutico , Transplante de Rim , Infecções por Parvoviridae/diagnóstico , Parvovirus B19 Humano , Complicações Pós-Operatórias/virologia , Aplasia Pura de Série Vermelha/virologia , Adulto , Anticorpos Antivirais/sangue , Medula Óssea/patologia , DNA Viral/análise , Células-Tronco Hematopoéticas/patologia , Humanos , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Masculino , Infecções por Parvoviridae/tratamento farmacológico , Parvovirus B19 Humano/isolamento & purificação , Resultado do TratamentoRESUMO
OBJECTIVE. We describe the CT and pathologic features of malignant papillary neoplasms of the intrahepatic bile ducts in 15 patients. CONCLUSION. CT is a useful technique for revealing intraductal lesions, although the findings are nonspecific and variable. When intraductal masses or nodules are seen with localized dilatation of the intrahepatic bile ducts on CT scans, malignant papillary neoplasms of the intrahepatic bile ducts should be included in the differential diagnosis.
