1.
Chem Commun (Camb)
; 56(11): 1633-1636, 2020 Feb 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31939462
RESUMO
We utilized solution-phase biopanning to obtain a de novo peptide (LA12) that specifically bound to the core region of the human amylin monomer. LA12 stabilized the random coil conformation of amylin to suppress aggregation in a dose-dependent manner with the highest suppression effect of 78% and reduced the cytotoxicity of amylin.