Ocular cryptococcosis as a presenting manifestation of cryptococcal meningitis in a patient with HIV.

We describe a case of cryptococcal meningitis in a patient known to have HIV who presented initially with ocular cryptococcosis. This case highlights to clinicians the need to be aware of this association and to carry out relevant investigations so as to treat these patients appropriately.

Efficacy of medical therapy in the initial management of acute primary angle closure in Asians.

PURPOSE: Recent studies have advocated the use of laser iridoplasty or paracentesis in the initial management of patients with acute primary angle closure (APAC). The aim of this study was to ascertain the effectiveness of medical treatment consisting of topical and systemic intraocular pressure (IOP)-lowering agents in the initial management of APAC. METHODS: This was an observational case series of consecutive patients presenting with APAC at a Singapore hospital over 2 years. On diagnosis, all subjects received intravenous acetazolamide followed by oral acetazolamide, topical pilocarpine, timolol, and steroid eye drops. Resolution of APAC was defined as IOP <21 mm Hg with no acute symptoms. RESULTS: In all, 134 consecutive APAC subjects were studied. The majority of subjects were Chinese (96.3%) and female (80%), and the mean age was 63.7±9.6 years. The mean presenting IOP was 58±12.7 mm Hg and mean duration of symptoms was 2.8±3.2 days. With medical therapy, APAC attacks resolved within 3, 6, 12, and 24 h in 28 (21.5%), 58 (44.6%), 99 (76.2%), and 116 (89.2%) subjects, respectively. After resolution of APAC, laser iridotomy was performed in 81.6% of the subjects; 16.2% of the subjects underwent cataract extraction. There was failure of resolution of APAC in only 3 subjects (2.2%). No subject suffered any serious side effects as a result of treatment. CONCLUSIONS: Medical therapy resulted in resolution of APAC within 12 h in 76.2% of the subjects and within 24 h in 89.2% of the subjects, showing the effectiveness of medical therapy in the initial management of APAC.

Focal-plane processing architectures for real-time hyperspectral image processing.

Real-time image processing requires high computational and I/O throughputs obtained by use of optoelectronic system solutions. A novel architecture that uses focal-plane optoelectronic-area I/O with a fine-grain, low-memory, single-instruction-multiple-data (SIMD) processor array is presented as an efficient computational solution for real-time hyperspectral image processing. The architecture is evaluated by use of realistic workloads to determine data throughputs, processing demands, and storage requirements. We show that traditional store-and-process system performance is inadequate for this application domain, whereas the focal-plane SIMD architecture is capable of supporting real-time performances with sustained operation throughputs of 500-1500 gigaoperations/s. The focal-plane architecture exploits the direct coupling between sensor and parallel-processor arrays to alleviate data-bandwidth requirements, allowing computation to be performed in a stream-parallel computation model, while data arrive from the sensors.