[Intensification of surgical therapy of traumatic injury to the median and ulnar nerves in the acute period]. / Intensifikatsiia khirurgicheskogo lecheniia travmaticheskogo povrezhdeniia sredinnogo i loktevogo nervov v ostrom periode.

The results of experimental development of the use of Quercitrol, the inhibitor of leukotrienes, and helium-neon laser acupuncture for the treatment of antiinflammatory operative neuroma decelerating the process of neural tissue regeneration are presented. The positive data of the experiments have been confirmed in the clinic.

[Characteristics of the reactions of popliteal and medial iliac lymph nodes after plastic surgery of the sciatic nerve defect using cryopreserved allogeneic transplant]. / Osobennosti reaktsii podkolennykh i medial'nykh podvzdoshnykh limfaticheskikh uzlov pri plastike defekta sedalishnogo nerva kriokonservirovannym allotransplantatom.

Histologically and morphometrically structural transformations in the popliteal and iliac medial lymph nodes have been studied in dogs at plasty of their ischiatic nerve by means of a cryopreserved allotransplant. In one week after the operation in the popliteal and in one month in the iliac nodes appear and then develop further certain reactions in B-dependent areas. In 4-12 weeks after the nerve transplantation certain statistically significant changes are noted in the thymus-dependent zone of the iliac medial lymph nodes. During first two weeks from the beginning of the experiment increase in the relative area of the popliteal lymph nodes sinuses is observed. The transformations described are interpreted as a response of the immune system to the nerve cut, and as a result of it--denervation of the crural tissues, disturbance of their nervous trophic, as well as--to transplantation of the allogeneic nervous trunk. The data obtained are in accordance with results of immunological investigations.

[The reinnervation of the gastrocnemius muscle following the plastic repair of a sciatic nerve defect with a cryopreserved allograft]. / Reinnervatsiia ikronozhnoi myshtsy posle plastiki defekta sedalishchnogo nerva kriokonservirovannym allotransplantatom.

A correlation between electrophysiological and morphological indices during reinnervation of the gastrocnemius muscle in the experimental alloneuroplastics of the sciatic nerve defect by the cryopreserved graft was determined. Data obtained show that the alloneuroplastics can provide axon regeneration and restoration of the operated limb function.

[The effect of para-aminomethylbenzoic acid (amben) on peripheral nerve regeneration]. / Vliianie paraaminometilbenzoinoi kisloty (ambena) na regeneratsiiu perifericheskogo nerva.

Various injuries to the sciatic nerve were modelled in experiments on 60 rats and 27 dogs to study the effect of paraaminomethylbenzoic acid on its regeneration; the efficacy of amben was compared with that of other agents used widely for the treatment of injuries to nerves. It was found that amben acts on the connective tissue of the neural scar and creates favourable conditions for growth of axons from the central to the peripheral stump of the injured nerve and accelerated their maturation.

[Surgical treatment of sequelae of nerve trunk injuries of the lower limbs]. / Khirurgicheskoe lechenie posledstvii travm nervnykh stvolov nizhnikh konechnostei.

The authors have analysed the results of surgical treatment of 63 patients with consequences of traumatic injuries of the nerves of the lower extremities. Characteristic peculiarities of the injuries of the nerves of the lower extremities are noted. The possibilities of reconstructive microsurgery in the treatment of severe traumatic lesions in this contingent of the patients are demonstrated.

[Ultrastructure of a sciatic nerve allograft preserved at an ultralow temperature]. / Ul'trastruktura allotransplantata sedalishchnogo nerva, konservirovannogo pri ul'tranizkoi temperature.

In the experiment, performed on dogs ultrastructure of the ischiatic nerve allograft, preserved in liquid nitrogen (-196 degrees) has been studied. In 7 days after the operation in the transplanted piece of the nerve trunk certain phenomena, similar to the Wallerian degeneration are noted, while viability of neurilemma cells is preserved. Processes of second degeneration are mainly completed by the end of the first month after the operation. During this time active regeneration of nervous fibers is noted; it is accompanied with neutralization of the graft. The latter is mostly expressed in 6 months after the operation. The dynamics studied on ultramicroscopic rearrangements of the cryopreserved graft proves the previously obtained data on possibility of its use in clinics for substitution of defects in peripheral nerves.

[2-stage microsurgical autoneuroplasty under pharmacologic effects (experimental research)]. / Dvukhétapnaia mikrokhirurgicheskaia autoneiroplastika v usloviiakh farmakologicheskogo vozdeistviia (éksperimental'noe issledovanie).

It is shown in experiments on 36 dogs that two-stage microsurgical autoneuroplasty with subsequent administration of an inhibitor of proteolytic enzymes (aminocaproic acid), an antioxidant (tocopherol acetate) and heparin makes it possible to realize more fully the histoblastic potencies of tissues which are components of the injured nerve and the graft. This circumstance leads to the improvement of the morphofunctional results of sciatic nerve restoration after its experimental injury.

[Alloplasty of nerves using cryopreserved grafts subjected to total epineurectomy (experimental-clinical study)]. / Alloplastika nervov kriokonserivirovannym transplantatom, podvergnutym total'noi épinevrektomii (eksperimental'no-klinicheskoe issledovanie).

It was demonstrated in experiments on 24 dogs that microsurgical epineurectomy of a cryopreserved peripheral nerve improves the results of neuroplasty due to acceleration and increase of graft revascularization. From application of the developed method in 12 patients it was concluded that microsurgical alloneuroplasty with a cryopreserved graft may be the method of choice in cases in which autoplasty cannot be performed.

[Regeneration of the sciatic nerve after plastic repair of a defect in it using a cryopreserved allograft]. / Regeneratsiia sedalishchnogo nerva posle plastiki ego defekta kriokonservirovannym allotransplantatom.

A correlation between morphological and electrophysiological indices in the experimental alloneuroplastic of the sciatic nerve defect by the cryopreserved graft was determined. Data obtained permit recommending alloneuroplastic by cryopreserved graft for treatment of the peripheral nerve damage.