Study of absorption of radio frequency field by gold nanoparticles and nanoclusters in biological medium.

Gold nanoparticles (AuNPs) and gold nanoclusters (AuNCs) are gaining interest in medical diagnosis and therapy as they are bio-compatible and are easy to functionalize. Their interaction with radiofrequency (RF) field for hyperthermia treatment is ambiguous and needs further investigation. A systematic study of the absorption of capacitive RF field by AuNPs and AuNCs dispersed in phosphate-buffered saline (PBS) is reported here in tissue mimicking phantom. The stability of AuNPs and AuNCs dispersed in PBS was confirmed for a range of pH and temperature expected during RF hyperthermia treatment. Colloidal gold solutions with AuNPs (10 nm) and AuNCs (2 nm), and control, i.e. PBS without nanogold, were loaded individually in 3 ml wells in a tissue phantom. Phantom heating was carried out using 27 MHz short-wave diathermy equipment at 200 and 400 W for control and colloidal gold solutions. Experiments were conducted for colloidal gold at varying gold concentrations (10-100 µg/ml). Temperature rise measured in the phantom wells did not show dependence on the concentration and size of the AuNPs. Furthermore, temperature rise recorded in the control was comparable with the measurements recorded in both nanogold suspensions (2, 10 nm). Dielectric property measurements of control and colloidal gold showed <3% difference in electrical conductivity between the control and colloidal gold for both nanoparticle sizes. From the measurements, it is concluded that AuNPs and AuNCs do not enhance the absorption of RF-capacitive field and power absorption observed in the biological medium is due to the ions present in the medium.

Design and characterisation of miniaturised cavity-backed patch antenna for microwave hyperthermia.

PURPOSE: The aim of this study was to describe the design and characterisation of a miniaturised 434 MHz patch antenna enclosed in a metal cavity for microwave hyperthermia treatment of cancer. MATERIALS AND METHODS: Electromagnetic (EM) field distribution in the near field of a microstrip patch irradiating body tissue was studied using finite element method (FEM) simulations. Antenna miniaturisation was achieved through dielectric loading with very high permittivity, metal enclosure, patch folding and shorting post. Frequency dependent electrical properties of materials were incorporated wherever appropriate using dispersion model and measurements. Antenna return loss and specific absorption rate (SAR) at 434 MHz were measured on muscle phantoms for characterisation. RESULTS: The design was progressively optimised to yield a compact 434 MHz patch (22 mm × 8.8 mm × 10 mm) inside a metal cavity (40 mm × 12 mm) with integrated coupling water bolus (35 mm). The fabricated antenna with integrated water bolus was self resonant at 434 MHz without load, and has better than -10 dB return loss (S11) with 13-20 MHz bandwidth on two different phantoms. SAR at 434 MHz measured using an infrared (IR) thermal camera on split phantoms indicated penetration depth for -3 dB SAR as 8.25 mm compared to 8.87 mm for simulation. The simulated and measured SAR coverage along phantom depth was 3.09 cm(2) and 3.21 cm(2) respectively at -3 dB, and 6.42 cm(2) and 9.07 cm(2) respectively at -6 dB. SAR full width at half maximum (FWHM) at 5 mm and 20 mm depths were 54.68 mm and 51.18 mm respectively in simulation, and 49.47 mm and 43.75 mm respectively in experiments. Performance comparison of the cavity-backed patch indicates more than 89% co-polarisation and higher directivity which resulted in deeper penetration compared to the patch applicators of similar or larger size proposed for hyperthermia treatment of cancer. CONCLUSION: The fabricated cavity-backed applicator is self-resonant at 434 MHz with a negligible shift in resonance when coupled to different phantoms, Δf/f0 less than 1.16%. IR thermography-based SAR measurements indicated that the -3 dB SAR of the cavity-backed aperture antenna covered the radiating aperture surface at 5 mm and 20 mm depths. It can be concluded that the compact cavity-backed patch antenna has stable resonance, higher directivity and low cross polarisation, and is suitable for design of microwave hyperthermia array applicators with adjustable heating pattern for superficial and/or deep tissue heating.

A compact microwave patch applicator for hyperthermia treatment of cancer.

Design and development of a compact microstrip C-type patch applicator for hyperthermia treatment of cancer is presented. The patch antenna is optimized for resonance at 434 MHz, return loss (S11) better than -15dB and co-polarized electric field in tissue. Effect of water bolus thickness on power delivery is studied for improved power coupling. Numerical simulations for antenna design optimization carried out using EM simulation software, Ansys HFSS(®), USA were experimentally verified. The effective field coverage for the optimized patch antenna and experimental results indicate that the compact antenna resonates at ISM frequency 434 MHz with better than -15 dB power coupling.