RESUMO
The aim of the study was to evaluate efficacy of adepress (paroxetin) in different clinical variants of generalized anxiety disorder (GAD). Adepress was used as a monotherapy during 42 days. Patient's state was assessed using Hamilton anxiety scale (HAM-A) at baseline and every week thereafter. The study included 49 patients aged 36,2+/-8,2 years. Patients were stratified into two groups according to the predominance of somatic (24 cases) or cognitive (21 cases) anxiety. The efficacy of adepress was shown both in a separate GAD and in a GAD with comorbid psychopathology. The effect of the drug was seen in patients with somatic anxiety after 3-4 weeks and in patients with cognitive anxiety after 3-6 weeks.
Assuntos
Antidepressivos de Segunda Geração/uso terapêutico , Transtornos de Ansiedade/tratamento farmacológico , Paroxetina/uso terapêutico , Inibidores Seletivos de Recaptação de Serotonina/uso terapêutico , Adolescente , Adulto , Feminino , Humanos , Masculino , Escala de Ansiedade Manifesta , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto JovemAssuntos
Antipsicóticos/uso terapêutico , Dibenzotiazepinas/uso terapêutico , Esquizofrenia/tratamento farmacológico , Adolescente , Adulto , Antipsicóticos/efeitos adversos , Dibenzotiazepinas/efeitos adversos , Humanos , Pessoa de Meia-Idade , Fumarato de Quetiapina , Indução de Remissão , Fatores de TempoRESUMO
The authors studied therapeutic properties of fluoxetine in the treatment of 100 patients with endogenous depressions. The drug was introduced during 6 weeks in a daily dose 20 mg. On the basis of the analysis of its clinical action and adverse reactions, fluoxetine belonging to the class of antidepressants has been ascertained. A prevalence of thymoleptic and stimulating components in its action, equal by their degree of expressivity and a smaller degree of anxiolytic effect have been demonstrated. Differentiated indications to fluoxetine prescription, its predilection in the therapy of apatho-adynamic and melancholic depressions and the feasibility of its use in inpatient conditions are discussed.
Assuntos
Fluoxetina/uso terapêutico , Adolescente , Adulto , Idoso , Transtorno Depressivo/tratamento farmacológico , Transtorno Depressivo/psicologia , Feminino , Fluoxetina/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Testes Psicológicos , Psicopatologia , Indução de Remissão , Comprimidos , Fatores de TempoRESUMO
Analysis of the daily dynamics of some physiological and psychoemotional characteristics in healthy subjects and depressed patients has demonstrated the patients to have circadian rhythm disorders in functions, namely inversion of the daily gradient with the shift of the function optimum to the second half of the day. The depressed patients manifested a high daily variability of the physiological parameters. It should be mentioned that curable conditions were marked by a higher variability as compared to those resistant to the treatment. The latter circumstance permits regarding the ratio of function variability as a potential predictor.
