RESUMO
Flow cytometric cell cycle analysis was recorded in gastric biopsy specimens from patients with normal gastric mucosa (GM), superficial gastritis (SG) and chronic atrophic gastritis (CAG). Cell-cycle analysis showed significantly higher percentages of cells in S- and S+G2/M-phase in CAG than in SG and normal GM (P < 0.0001). Moreover, CAG with severe or moderate atrophy showed significantly higher percentages of cells in S-phase (P < 0.05) and S+G2/M-phase (P < 0.02) than CAG with mild atrophy in antrum. In fundus, even if this increase was observed, it did not reach statistical significance. Consideration of concomitant pathologic findings such as oesophagite, gastric or duodenal ulcer, duodenite or benign polyp allowed a better differentiation of CAG both in antrum and in fundus. Significantly higher S-phase was observed in CAG with severe or moderate atrophy than in CAG with mild atrophy (P < 0.05). No statistically significant results were observed in patients with normal gastric mucosa or chronic gastritis and a concomitant pathologic finding.
Assuntos
Mucosa Gástrica/patologia , Gastrite Atrófica/patologia , Gastrite/patologia , Ciclo Celular/fisiologia , Doença Crônica , Endoscopia Gastrointestinal , Feminino , Citometria de Fluxo , Humanos , MasculinoRESUMO
Rectal route with local or general effects, is an interesting possibility of treatment. Easy use and rapid absorption are two major advantages. But this therapeutic modality is not riskless. We report a case of septicemia with peri-rectal cellulitis which was generated by two ano-rectal ulcerations after using Trophires suppositories. The infection was favoured by local application of cortisone. Our original observation, with ano-rectal ulcerations and short use of suppository, confirms the idea of short-term treatment stopped in case of unwanted symptom.
Assuntos
Celulite (Flegmão)/induzido quimicamente , Proctite/induzido quimicamente , Sepse/induzido quimicamente , Supositórios/efeitos adversos , Adulto , Feminino , HumanosAssuntos
Doenças do Esôfago/etiologia , Gastrostomia/efeitos adversos , Neoplasias Faríngeas/cirurgia , Carcinoma de Células Escamosas/cirurgia , Doenças do Esôfago/diagnóstico por imagem , Humanos , Laringectomia , Masculino , Pessoa de Meia-Idade , Faringectomia , Complicações Pós-Operatórias , RadiografiaAssuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Cromolina Sódica/uso terapêutico , Enterocolite , Metaloproteínas/efeitos adversos , Compostos Organometálicos , Dimercaprol/efeitos adversos , Enterocolite/induzido quimicamente , Enterocolite/tratamento farmacológico , Feminino , Humanos , Pessoa de Meia-Idade , Compostos Organoáuricos , Propanóis , Compostos de SulfidrilaRESUMO
Bone surveys represent a particular problem in the investigation of secondary tumours, especially in the case of small cell cancer. This study was based on 70 patients in which qualitative criteria (clinical, radiographic, bone scan, bone aspiration-biopsy) replaced quantitative criteria (calcium, alkaline phosphatase, phosphorus). The histological (BPO) and clinical (pain) markers were determinant in the prognosis; in contrast, the repetition of the bone scan in the evaluation of response to treatment is only of very limited value.
