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Radiologia (Engl Ed) ; 65 Suppl 1: S11-S20, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37024226

RESUMO

Traumatic injuries can be severe and complex, requiring the coordinated efforts of a multidisciplinary team. Imaging tests play a fundamental role in rapid and accurate diagnosis. In particular, whole-body computed tomography (CT) has become a key tool. There are different CT protocols depending on the patient's condition; whereas dose-optimized protocols can be used in stable patients, time/precision protocols prioritizing speed at the cost of delivering higher doses of radiation should be used in more severe patients. In unstable patients who cannot be examined by CT, X-rays of the chest and pelvis and FAST or e-FAST ultrasound studies, although less sensitive than CT, enable the detection of situations that require immediate treatment. This article reviews the imaging techniques and CT protocols for the initial hospital workup for patients with multiple trauma.


Assuntos
Traumatismo Múltiplo , Humanos , Traumatismo Múltiplo/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Radiografia , Ultrassonografia , Literatura de Revisão como Assunto
3.
Radiologia (Engl Ed) ; 65 Suppl 1: S81-S91, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37024234

RESUMO

Acute appendicitis is the most common indication for emergency abdominal surgery throughout the world and a common reason for consultation in emergency departments. In recent decades, diagnostic imaging has played a fundamental role in identifying acute appendicitis, helping to reduce the rate of blind laparotomies and hospital costs. Given the results of clinical trials supporting the use of antibiotic therapy over surgical treatment, radiologists need to know the diagnostic criteria for complicated acute appendicitis to be able to recommend the best treatment option. This review aims not only to define the diagnostic criteria for appendicitis in different imaging modalities (ultrasonography, computed tomography, and magnetic resonance imaging), but also to explain the diagnostic protocols, atypical presentations, and other conditions that can mimic appendicitis.


Assuntos
Apendicite , Humanos , Apendicite/diagnóstico por imagem , Apendicite/cirurgia , Apendicectomia , Abdome , Ultrassonografia , Tomografia Computadorizada por Raios X , Doença Aguda
4.
Radiologia (Engl Ed) ; 64(6): 506-515, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36402536

RESUMO

OBJECTIVE: To analyze the evolution of the use of imaging tests (ultrasonography and computed tomography (CT)) in the diagnosis of acute appendicitis. To determine the positive predictive value of these tests and the percentage of negative and complicated appendectomies. MATERIAL AND METHODS: This retrospective study compared adults who underwent appendectomy for suspected acute appendicitis at our tertiary hospital during 2015 versus similar patients at our center during 2007. RESULTS: A total of 278patients were included. The rate of negative appendectomies descended to 5%. The positive predictive value of ultrasonography increased to 97.4% in 2015, and the positive predictive value of CT and combined CT and ultrasonography was 100%. The rate of complicated appendicitis increased (23% in 2015). CONCLUSIONS: The use of imaging tests increased, and the rate of "blind" laparotomies decreased. Nevertheless, the rate of complicated appendicitis increased.


Assuntos
Apendicite , Humanos , Adulto , Apendicite/diagnóstico por imagem , Apendicite/cirurgia , Estudos Retrospectivos , Valor Preditivo dos Testes , Ultrassonografia , Tomografia Computadorizada por Raios X/métodos , Doença Aguda
5.
Radiología (Madr., Ed. impr.) ; 64(6): 506-515, Nov-Dic. 2022. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-211647

RESUMO

Objetivo: Analizar la evolución del uso de pruebas de imagen (ecografía y tomografía computarizada [TC]) en el diagnóstico de apendicitis aguda, el valor predictivo positivo (VPP) y determinar el porcentaje de apendicectomías negativas y complicadas. Material y métodos: Estudio retrospectivo que incluye a los pacientes adultos con apendicectomía por sospecha de apendicitis aguda en 2015 en un hospital terciario. Se compara con los del 2007 publicados previamente. Resultados: La muestra incluye 278 pacientes. La tasa de apendicectomías negativas descendió a un 5%. El VPP de la ecografía aumentó a 97,4% en 2015 y el VPP de la TC y del uso combinado de la ecografía y la TC fue del 100%. El porcentaje de apendicitis complicadas se incrementó (23% en 2015). Conclusiones: Se observó un aumento en el empleo de pruebas de imagen y una disminución de laparotomías en blanco. No obstante, las apendicitis complicadas se han incrementado.(AU)


Objective: To analyze the evolution of the use of imaging tests (ultrasonography and computed tomography (CT)) in the diagnosis of acute appendicitis. To determine the positive predictive value of these tests and the percentage of negative and complicated appendectomies. Material and methods: This retrospective study compared adults who underwent appendectomy for suspected acute appendicitis at our tertiary hospital during 2015 versus similar patients at our center during 2007. Results: A total of 278 patients were included. The rate of negative appendectomies descended to 5%. The positive predictive value of ultrasonography increased to 97.4% in 2015, and the positive predictive value of CT and combined CT and ultrasonography was 100%. The rate of complicated appendicitis increased (23% in 2015). Conclusions: The use of imaging tests increased, and the rate of “blind” laparotomies decreased. Nevertheless, the rate of complicated appendicitis increased.(AU)


Assuntos
Humanos , Masculino , Feminino , Apendicite/diagnóstico , Ultrassonografia , Tomografia Computadorizada por Raios X , Valor Preditivo dos Testes , Apendicite/classificação , Radiologia , Serviço Hospitalar de Radiologia , Diagnóstico por Imagem , Estudos Retrospectivos
6.
Radiologia (Engl Ed) ; 63(1): 56-73, 2021.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33339622

RESUMO

The pandemia caused by the SARS-CoV-2 virus has triggered an unprecedented health and economic crisis. Although the diagnosis of infection with SARS-CoV-2 is microbiological, imaging techniques play an important role in supporting the diagnosis, grading the severity of disease, guiding treatment, detecting complications, and evaluating the response to treatment. The lungs are the main organ involved, and chest X-rays, whether obtained in conventional X-ray suites or with portable units, are the first-line imaging test because they are widely available and economical. Chest CT is more sensitive than plain chest X-rays, and CT studies make it possible to identify complications in addition to pulmonary involvement, as well as to suggestive alternative diagnoses. The most common radiologic findings in COVID-19 are airspace opacities (consolidations and/or ground-glass opacities), which are typically bilateral, peripheral, and located primarily in the lower fields.


Assuntos
COVID-19/diagnóstico por imagem , Radiografia Torácica , Tomografia Computadorizada por Raios X , Humanos
7.
Radiologia (Engl Ed) ; 63(1): 13-21, 2021.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33228959

RESUMO

INTRODUCTION: SARS-CoV-2, the virus responsible for the current pandemic, predominantly affects the respiratory tract, and a growing number of publications report the predisposition of patients with COVID-19 to develop thrombotic phenomena. OBJECTIVE: To determine the prevalence of pulmonary embolism in patients with COVID-19; to determine the possible relationship between the severity of pulmonary involvement and D-dimer levels; to analyze the location of pulmonary embolisms in patients with COVID-19 and to compare it with the location in patients without COVID-19. METHODS: This retrospective study analyzed all CT angiograms of the pulmonary arteries done in patients with suspected pulmonary embolisms between March 15 and April 30, 2020 and compared them with studies done in the same period one year earlier. RESULTS: We included 492 pulmonary CT angiograms (342 (69.9%) in patients with COVID-19 and 147 (30.1%) in patients without COVID-19). The prevalence of pulmonary embolisms was higher in patients with COVID-19 (26% vs. 16.3% in patients without COVID-19, p=0.0197; relative risk=1.6). The prevalence of pulmonary embolisms in the same period in 2019 was 13.2%, similar to that of the group of COVID-19-negative patients in 2020 (p=0.43). There were no significant differences in D-dimer levels or the location of pulmonary embolisms between the two groups. CT showed moderate or severe pulmonary involvement in 78.7% of the patients with COVID-19. CONCLUSIONS: Patients with COVID-19 have an increased prevalence of pulmonary embolisms (26%), and most (78.7%) have moderate or severe lung involvement on CT studies. The location of pulmonary embolisms and the degree of elevation of D-dimer levels does not differ between patients with COVID-19 and those without.


Assuntos
COVID-19/complicações , Embolia Pulmonar/epidemiologia , Embolia Pulmonar/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Angiografia por Tomografia Computadorizada , Feminino , Produtos de Degradação da Fibrina e do Fibrinogênio/análise , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Embolia Pulmonar/sangue , Embolia Pulmonar/diagnóstico por imagem , Estudos Retrospectivos , Índice de Gravidade de Doença , Centros de Atenção Terciária
8.
Radiologia (Engl Ed) ; 63(1): 22-31, 2021.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33008619

RESUMO

OBJECTIVE: Puerperium is the period during which the physiological changes that have taken place during pregnancy revert and the uterus involutes until it reaches its normal size. This is a period of intense systemic changes, and diagnosing complications in this period is a challenge for both gynecologists and radiologists. This paper reviews the complications that can occur during puerperium, classifying them according to the pathophysiological mechanisms involved: the prothrombotic state, hemodynamic and hormonal changes, rapid uterine growth, changes associated with endothelial damage (preeclampsia, eclampsia, and HELLP syndrome), and postoperative complications in patients undergoing cesarean sections. CONCLUSION: Puerperal complications represent a diagnostic challenge. Understanding the pathophysiological mechanisms underlying these complications is fundamental for choosing the most appropriate imaging technique to ensure the correct diagnosis in each case.

9.
Radiología (Madr., Ed. impr.) ; 63: 0-0, 2021. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-196554

RESUMO

La pandemia por el virus SARS-CoV-2ha desencadenado una crisis económica y sanitaria sin precedentes. Aunque el diagnóstico es microbiológico, las técnicas de imagen tienen un papel importante para apoyar el diagnóstico, graduar la gravedad de la enfermedad, guiar el tratamiento, detectar posibles complicaciones y valorar la respuesta terapéutica. La afectación es principalmente pulmonar. La radiografía de tórax en sala convencional o portátil es el primer método de imagen por su amplia disponibilidad y bajo coste. La tomografía computarizada torácica tiene una mayor sensibilidad que la radiografía de tórax y permite valorar tanto la afectación pulmonar como posibles complicaciones, además de proporcionar diagnósticos alternativos. Los hallazgos radiológicos más frecuentes son las opacidades del espacio aéreo en forma de consolidaciones y/u opacidades en vidrio deslustrado, con distribución típicamente bilateral, periférica y de predominio en los campos inferiores


The pandemia caused by the SARS-CoV-2 virus has triggered an unprecedented health and economic crisis. Although the diagnosis of infection with SARS-CoV-2 is microbiological, imaging techniques play an important role in supporting the diagnosis, grading the severity of disease, guiding treatment, detecting complications, and evaluating the response to treatment. The lungs are the main organ involved, and chest X-rays, whether obtained in conventional X-ray suites or with portable units, are the first-line imaging test because they are widely available and economical. Chest CT is more sensitive than plain chest X-rays, and CT studies make it possible to identify complications in addition to pulmonary involvement, as well as to suggestive alternative diagnoses. The most common radiologic findings in COVID-19 are airspace opacities (consolidations and/or ground-glass opacities), which are typically bilateral, peripheral, and located primarily in the lower fields


Assuntos
Humanos , Idoso , Idoso de 80 Anos ou mais , Infecções por Coronavirus/diagnóstico por imagem , Pneumonia Viral/diagnóstico por imagem , Pandemias , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X , Sensibilidade e Especificidade , Fatores de Risco , Radiografia
10.
Radiologia (Engl Ed) ; 2020 Dec 14.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33334589

RESUMO

OBJECTIVE: To analyze the evolution of the use of imaging tests (ultrasonography and computed tomography (CT)) in the diagnosis of acute appendicitis. To determine the positive predictive value of these tests and the percentage of negative and complicated appendectomies. MATERIAL AND METHODS: This retrospective study compared adults who underwent appendectomy for suspected acute appendicitis at our tertiary hospital during 2015 versus similar patients at our center during 2007. RESULTS: A total of 278 patients were included. The rate of negative appendectomies descended to 5%. The positive predictive value of ultrasonography increased to 97.4% in 2015, and the positive predictive value of CT and combined CT and ultrasonography was 100%. The rate of complicated appendicitis increased (23% in 2015). CONCLUSIONS: The use of imaging tests increased, and the rate of "blind" laparotomies decreased. Nevertheless, the rate of complicated appendicitis increased.

11.
Radiología (Madr., Ed. impr.) ; 62(4): 280-291, jul.-ago. 2020. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-194245

RESUMO

Una fístula aortoentérica (FAE) es una comunicación aberrante entre la aorta y la pared del tubo digestivo. Se trata de una entidad rara pero con alta mortalidad que requiere, por tanto, un diagnóstico certero y precoz. Se clasifica como primaria si se desarrolla sobre una aorta nativa no intervenida previamente o como secundaria cuando ocurre en un contexto de complicación posquirúrgica de reparación vascular. Todo radiólogo debería saber reconocer los signos directos e indirectos que pudieran sugerir la existencia de una FAE. En este artículo se revisan los tipos de FAE y su correlación clínico-fisiopatológica, así como el algoritmo diagnóstico exponiendo los hallazgos radiológicos típicos en tomografía computarizada


An aortoenteric fistula is an abnormal communication between the aorta and the gastrointestinal tract wall. The high mortality associated with this rare entity means it requires early accurate diagnosis. Aortoenteric fistulas are classified as primary when they develop on a native aorta that has not undergone an intervention and as secondary when they develop after vascular repair surgery. All radiologists need to be able to recognize the direct and indirect signs that might suggest the presence of an aortoenteric fistula. This article reviews the types of aortoenteric fistulas and their clinical and pathophysiological correlation, as well as the diagnostic algorithm, illustrating the most characteristic findings on multidetector computed tomography


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Doenças da Aorta/diagnóstico por imagem , Fístula do Sistema Digestório/diagnóstico por imagem , Fístula Vascular/diagnóstico por imagem , Angiografia , Tomografia Computadorizada por Raios X
12.
Radiologia (Engl Ed) ; 62(4): 280-291, 2020.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-32245628

RESUMO

An aortoenteric fistula is an abnormal communication between the aorta and the gastrointestinal tract wall. The high mortality associated with this rare entity means it requires early accurate diagnosis. Aortoenteric fistulas are classified as primary when they develop on a native aorta that has not undergone an intervention and as secondary when they develop after vascular repair surgery. All radiologists need to be able to recognize the direct and indirect signs that might suggest the presence of an aortoenteric fistula. This article reviews the types of aortoenteric fistulas and their clinical and pathophysiological correlation, as well as the diagnostic algorithm, illustrating the most characteristic findings on multidetector computed tomography.


Assuntos
Doenças da Aorta/diagnóstico por imagem , Fístula Intestinal/diagnóstico por imagem , Tomografia Computadorizada Multidetectores , Fístula Vascular/diagnóstico por imagem , Idoso , Idoso de 80 Anos ou mais , Doenças da Aorta/diagnóstico , Humanos , Fístula Intestinal/diagnóstico , Masculino , Pessoa de Meia-Idade , Fístula Vascular/diagnóstico
13.
RSC Adv ; 10(66): 40127-40135, 2020 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-35520832

RESUMO

A new series of heteroaryl nitrones were synthesized and evaluated as free radical traps due to the results showed in our previous report. The physicochemical characterization of these new nitrones by electron spin resonance (ESR) demonstrated their high capability to trap and stabilize different atom centered free radicals generated by the Fenton reaction. Additionally, we intensely studied them in terms of their physicochemical properties. Kinetic studies, including the use of a method based on competition and the hydroxyl adduct decay, gave the corresponding rate constants and half-lives at the physiological pH of these newly synthesized nitrones. New nitrones derived from quinoxaline 1,4-dioxide heterocycles were more suitable than DMPO to trap hydroxyl free radicals with a half-life longer than two hours. We explain some of the results using computational chemistry through density functional theory (DFT).

14.
Radiología (Madr., Ed. impr.) ; 62: 0-0, 2020. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-195066

RESUMO

INTRODUCCIÓN: El coronavirus SARS-CoV-2, responsable de la pandemia actual, afecta preferentemente al tracto respiratorio, con un número creciente de publicaciones sobre su predisposición a fenómenos trombóticos. OBJETIVO: Conocer la prevalencia de tromboembolismo pulmonar (TEP) en pacientes con COVID-19; determinar su posible relación con la gravedad de la enfermedad pulmonar y los niveles de dímeros D, y analizar la localización del TEP en pacientes con COVID-19 comparándolos con los pacientes sin COVID-19. MÉTODO: Estudio retrospectivo de todas las angio-TC de arterias pulmonares realizadas por sospecha de TEP del 15 de marzo al 30 de abril de 2020. Se compara con las angio-TC realizadas durante el mismo periodo en 2019. RESULTADOS: Se incluyeron 492 angio-TC pulmonares, 342 (69,9%) de pacientes con COVID-19 y 147 (30,1%) de pacientes sin infección. La prevalencia de TEP fue del 26% en el grupo COVID-19 positivo y del 16,3% en el negativo (p = 0,0197), con un riesgo relativo de 1,6 veces. La prevalencia de TEP en el mismo período del año 2019 fue del 13,2%, similar a la del grupo COVID-19 negativo del año 2020 (p = 0,43). No hubo diferencias significativas en el nivel de dímeros D ni en la localización del TEP entre ambos grupos. El 78,7% de los pacientes con COVID-19 con TEP mostraron una extensión de la afectación pulmonar moderada o grave en la tomografía computarizada. CONCLUSIONES: Los pacientes con COVID-19 tienen una prevalencia aumentada de TEP (26%) y la mayoría (78,7%) presentan una extensión moderada o grave de afectación pulmonar en la tomografía computarizada. No hay diferencias significativas en la localización del material embólico ni en el grado de elevación de dímero-D respecto a los pacientes sin COVID-19


INTRODUCTION: SARS-CoV-2, the virus responsible for the current pandemic, predominantly affects the respiratory tract, and a growing number of publications report the predisposition of patients with COVID-19 to develop thrombotic phenomena. OBJECTIVE: To determine the prevalence of pulmonary embolism in patients with COVID-19; to determine the possible relationship between the severity of pulmonary involvement and D-dimer levels; to analyze the location of pulmonary embolisms in patients with COVID-19 and to compare it with the location in patients without COVID-19. METHODS: This retrospective study analyzed all CT angiograms of the pulmonary arteries done in patients with suspected pulmonary embolisms between March 15 and April 30, 2020 and compared them with studies done in the same period one year earlier. RESULTS: We included 492 pulmonary CT angiograms (342 (69.9%) in patients with COVID-19 and 147 (30.1%) in patients without COVID-19). The prevalence of pulmonary embolisms was higher in patients with COVID-19 (26% vs. 16.3% in patients without COVID-19, p = 0.0197; relative risk=1.6). The prevalence of pulmonary embolisms in the same period in 2019 was 13.2%, similar to that of the group of COVID-19-negative patients in 2020 (p = 0.43). There were no significant differences in D-dimer levels or the location of pulmonary embolisms between the two groups. CT showed moderate or severe pulmonary involvement in 78.7% of the patients with COVID-19. CONCLUSIONS: Patients with COVID-19 have an increased prevalence of pulmonary embolisms (26%), and most (78.7%) have moderate or severe lung involvement on CT studies. The location of pulmonary embolisms and the degree of elevation of D-dimer levels does not differ between patients with COVID-19 and those without


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Infecções por Coronavirus/epidemiologia , Embolia Pulmonar/epidemiologia , Coronavírus Relacionado à Síndrome Respiratória Aguda Grave/patogenicidade , Síndrome Respiratória Aguda Grave/epidemiologia , Estudos Retrospectivos , Atenção Terciária à Saúde/estatística & dados numéricos , Pandemias/estatística & dados numéricos , Prevalência , Síndrome Respiratória Aguda Grave/complicações , Angiografia/métodos , Tomografia Computadorizada por Raios X/métodos , Artéria Pulmonar/diagnóstico por imagem
15.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 63(2): 86-94, mar.-abr. 2019. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-188890

RESUMO

Objetivo: El objetivo de este estudio es presentar nuestra serie de casos de sarcoma de Ewing y los datos de supervivencia obtenidos a medio plazo utilizando un protocolo de terapia multidisciplinar. Material, método y resultados: Cuarenta y un sarcomas de Ewing fueron diagnosticados, tratados y evolucionados en nuestro centro entre 2004 y 2009 con una media de edad de 18,29 años. Hasta un 78% correspondieron a Ewing óseo siendo el fémur la localización más frecuente. El 68% presentó un estadio localizado en el momento del diagnóstico. Al final del seguimiento la supervivencia no llegó al 40% de los pacientes, falleciendo la mayoría en los primeros 5 años de seguimiento. Discusión: En España, el sarcoma de Ewing es el tumor óseo maligno primario más frecuente en la infancia, por delante del osteosarcoma. Su tasa de supervivencia ha aumentado mucho en los últimos 40 años, mejoría atribuible fundamentalmente al uso agresivo de la quimioterapia y al tratamiento mutidisciplinar, pero su pronóstico sigue siendo muy pobre sobre todo en aquellos que presentan metástasis al diagnóstico, principal factor pronóstico adverso. Dada su alta mortalidad, son muchos los autores que lo consideran como una enfermedad diseminada desde el principio, con micrometástasis no detectables que son las que condicionan la supervivencia final. Conclusiones: El diagnóstico precoz y el tratamiento multidisciplinar en centros de referencia son las mejores estrategias con las que contamos en la actualidad para proporcionarles a los pacientes las máximas posibilidades de curación de esta enfermedad


Purpose: The purpose of this study is to present our series of Ewing sarcoma cases and the survival data obtained in the medium term, using a multidisciplinary therapy protocol. Material, methods and results: Forty-one Ewing sarcomas were diagnosed, treated and followed-up in our hospital between 2004 and 2009 with an average age of 18.29 years. Seventy-eight percent were to Ewing sarcoma of the bone, the femur being the most frequent location. Sixty-eight percent had a localized stage at the time of diagnosis. At the end of follow-up, 40% of the patients did not survive, most died within the first 5 years of follow-up. Discussion: In Spain, Ewing sarcoma is the most common primary malignant bone tumour in childhood, ahead of osteosarcoma. Its survival rate has increased greatly in the last 40 years, improvement attributable mainly to the aggressive use of chemotherapy and to multidisciplinary treatment, but its prognosis remains very poor, especially for those with metastasis at diagnosis, the main adverse prognostic factor. Because of its high mortality, many authors consider it a disseminated disease from the beginning, with non- detectable micrometastasis that condition final survival. Conclusions: Early diagnosis and multidisciplinary therapy in referral centres are the best strategies currently available to us to provide these patients the maximum possibilities of cure of this disease


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Neoplasias Ósseas/mortalidade , Neoplasias Ósseas/terapia , Equipe de Assistência ao Paciente , Sarcoma de Ewing/mortalidade , Sarcoma de Ewing/terapia , Estudos Retrospectivos , Análise de Sobrevida , Fatores de Tempo
16.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-30642764

RESUMO

PURPOSE: The purpose of this study is to present our series of Ewing sarcoma cases and the survival data obtained in the medium term, using a multidisciplinary therapy protocol. MATERIAL, METHODS AND RESULTS: Forty-one Ewing sarcomas were diagnosed, treated and followed-up in our hospital between 2004 and 2009 with an average age of 18.29 years. Seventy-eight percent were to Ewing sarcoma of the bone, the femur being the most frequent location. Sixty-eight percent had a localized stage at the time of diagnosis. At the end of follow-up, 40% of the patients did not survive, most died within the first 5 years of follow-up. DISCUSSION: In Spain, Ewing sarcoma is the most common primary malignant bone tumour in childhood, ahead of osteosarcoma. Its survival rate has increased greatly in the last 40 years, improvement attributable mainly to the aggressive use of chemotherapy and to multidisciplinary treatment, but its prognosis remains very poor, especially for those with metastasis at diagnosis, the main adverse prognostic factor. Because of its high mortality, many authors consider it a disseminated disease from the beginning, with non- detectable micrometastasis that condition final survival. CONCLUSIONS: Early diagnosis and multidisciplinary therapy in referral centres are the best strategies currently available to us to provide these patients the maximum possibilities of cure of this disease.


Assuntos
Neoplasias Ósseas/mortalidade , Neoplasias Ósseas/terapia , Equipe de Assistência ao Paciente , Sarcoma de Ewing/mortalidade , Sarcoma de Ewing/terapia , Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Análise de Sobrevida , Fatores de Tempo , Adulto Jovem
17.
Rev Neurol ; 67(4): 121-128, 2018 Aug 16.
Artigo em Espanhol | MEDLINE | ID: mdl-30039839

RESUMO

AIM: To assess the prognostic value of APACHE II and SAPS II scales to predict brain death evolution of neurocritical care patients. PATIENTS AND METHODS: Retrospective observational study performed in a tertiary hospital. Include 508 patients over 16 years old, hospitalized in ICU for at least 24 hours. The variables of interest were: demographic data, risk factors, APACHE II, SAPS II and outcome. RESULTS: Median age: 41 years old (IR: 25-57). Males: 76.2%. Most frequent reason for admission: trauma (55.3%). Medians: Glasgow Coma Scale (GCS), 10 points; APACHE II, 13 points; SAPS II, 31 points; and ICU stay, 5 days. Mortality in the ICU was 28.5% (n = 145) of whom 44 (8.7%) evolved to brain death. Univariate logistic regression analysis showed that GCS, APACHE II and SAPS II scores, as well as ICU stay days behaved as predictors of brain death evolution. However, the multivariate analysis performed including APACHE II and SAPS II scores showed that only APACHE II maintained statistical significance, despite the good discrimination of both scores. CONCLUSION: Transplant coordinators might use the APACHE II score as a tool to detect patients at risk of progression to brain death, minimizing the loss of potential donors.


TITLE: APACHE II y SAPS II como predictores de evolucion a muerte encefalica en pacientes neurocriticos.Objetivo. Evaluar si las escalas pronosticas APACHE II (Acute Physiology and Chronic Health Evaluation II) y SAPS II (Simplified Acute Physiology Score II) son capaces de predecir la evolucion a muerte encefalica en pacientes neurocriticos. Pacientes y metodos. Estudio retrospectivo, observacional, realizado en un hospital de tercer nivel. Se incluyo a 508 pacientes mayores de 16 años, ingresados con patologia neurocritica aguda, con estancia en la unidad de cuidados intensivos de al menos 24 horas. Las variables de interes fueron: datos demograficos, factores de riesgo, APACHE II, SAPS II y resultado pronostico. Resultados. Mediana de edad: 41 años (rango intercuartilico: 25-57). Varones: 76,2%. Motivo de ingreso mas frecuente: traumatismo (55,3%). Medianas: escala de coma de Glasgow (GCS), 10 puntos; APACHE II, 13 puntos; SAPS II, 31 puntos; y estancia en cuidados intensivos, cinco dias. La mortalidad en la unidad de cuidados intensivos fue de 145 (28,5%). De ellos, 44 (8,7%) evolucionaron a muerte encefalica. El analisis de regresion logistica univariante mostro que la GCS, las escalas APACHE II y SAPS II, y los dias de estancia en la unidad de cuidados intensivos se comportaron como variables predictoras de evolucion a muerte encefalica. Sin embargo, en el analisis multivariante realizado con APACHE II y SAPS II, se evidencio que solo APACHE II mantiene significacion estadistica, a pesar de la buena discriminacion de ambas escalas. Conclusion. Los coordinadores de trasplantes podrian usar la escala APACHE II como una herramienta para detectar pacientes con riesgo de evolucion a muerte encefalica, minimizando la perdida de potenciales donantes.


Assuntos
APACHE , Morte Encefálica/diagnóstico , Estado Terminal , Escore Fisiológico Agudo Simplificado , Adulto , Área Sob a Curva , Morte Encefálica/fisiopatologia , Causas de Morte , Feminino , Escala de Coma de Glasgow , Mortalidade Hospitalar , Humanos , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Curva ROC , Estudos Retrospectivos , Fatores de Risco , Sensibilidade e Especificidade , Centros de Atenção Terciária , Obtenção de Tecidos e Órgãos
18.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 62(2): 112-120, mar.-abr. 2018. tab, graf, ilus
Artigo em Espanhol | IBECS | ID: ibc-171622

RESUMO

Objetivo. Estudio retrospectivo de 98 fracturas diafisarias de antebrazo en adultos tratadas mediante osteosíntesis percutánea intramedular con agujas de Kirchner. Materiales y método. Se revisan 64 pacientes que presentaban 98 fracturas de antebrazo con un seguimiento clínico-radiológico, evaluando la presencia de seudoartrosis o retardo de la consolidación y valorando los resultados funcionales mediante la Escala de Anderson y el Disability of the Arm, Shoulder and Hand. Resultados. La consolidación clínica y radiológica se consiguió con una media de 12 semanas, obteniendo un 77% de excelentes y buenos resultados con los criterios de Anderson. Se registraron 4 casos de seudoartrosis y 6 casos de retardo de consolidación. Conclusión. La osteosíntesis percutánea presenta una serie de ventajas con respecto a otras técnicas como son una baja incidencia de complicaciones, ausencia de infecciones, refracturas y lesiones yatrogénicas vasculonerviosas. Se consigue una menor estancia hospitalaria y un acortamiento del tiempo quirúrgico, con unos resultados similares al tratamiento con placas y clavos endomedulares en cuanto a consolidación y resultados funcionales, como comprobamos al consultar la bibliografía publicada (AU)


Objective. This is a retrospective study of 98 diaphyseal forearm fractures in adults, treated by a percutaneous technique with intramedullar Kirchner wires. Materials and method. We reviewed 64 patients with 98 forearm fractures with a radiographic follow-up, assessing the presence of pseudarthrosis or delayed bone union and evaluating functional outcomes with the Anderson and the Disability of the Arm, Shoulder and Hand scale. Results. Clinical and radiological bone union was achieved in an average of 12 weeks. We obtained 77% of excellent and good results following Anderson's scale. There were 4 cases of pseudarthrosis and 6 cases of delayed bone union. Conclusion. This surgical technique provides several advantages, such as a low incidence of complications and a total absence of infections, refractures and iatrogenic neurovascular injuries. It allows a lower hospital stay and a shortening of the surgery time compared with other techniques such as plates and intramedullary nails, that have similar results, in terms of bone union and functional outcomes, as we have verified from the published literature (AU)


Assuntos
Humanos , Diáfises/lesões , Traumatismos do Antebraço/cirurgia , Fixação Interna de Fraturas/métodos , Fraturas Ósseas/cirurgia , Estudos Retrospectivos , Resultado do Tratamento , Recuperação de Função Fisiológica/fisiologia
19.
Transplant Proc ; 50(2): 530-532, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29579843

RESUMO

BACKGROUND: In all organ transplantation programs, election of the proper protocol relies primarily on the professionals involved in the detection of potential donors. The objective of our study was to assess the impact of a series of prehospital training sessions, as well as to develop several positive feedback strategies within the uncontrolled organ donation after circulatory death (uDCD) program in our city. METHODS: A before-after intervention study was carried out in 3 steps. First, professionals enrolled in the Emergency Health Services Agency-061 (EPES-061) program underwent specific training to identify potential donors. Second, a specific logotype was designed to alert emergency health care professionals that in cases where cardiopulmonary resuscitation was ineffective and after treatment of all potentially reversible causes, the "chain of survival" should be considered a "chain of opportunities." Third, a positive feedback strategy was put in place, whereby each time a donation was procured, the EPES-061 personnel that had identified the potential donor were notified by phone and in a personal letter. RESULTS: The mean age for donors was 50.5 years of age (interquartile range 37-52.5), and 89.5% of all donations came from male subjects. Positive feedback letters and phone calls, including information on final outcome, were provided to the appropriate personnel in 100% of the cases. Postintervention information showed an increase in both eligible and utilized donors. CONCLUSIONS: Interventions outside the hospital setting that facilitate optimal implementation of the uDCD program are an essential part of this strategy to increase the donor pool and make the wait shorter for transplant patients.


Assuntos
Seleção do Doador/métodos , Educação/métodos , Medicina de Emergência/educação , Implementação de Plano de Saúde/estatística & dados numéricos , Obtenção de Tecidos e Órgãos/organização & administração , Morte , Serviços Médicos de Emergência/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Programas e Projetos de Saúde , Espanha
20.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29306577

RESUMO

OBJECTIVE: This is a retrospective study of 98 diaphyseal forearm fractures in adults, treated by a percutaneous technique with intramedullar Kirchner wires. MATERIALS AND METHOD: We reviewed 64 patients with 98 forearm fractures with a radiographic follow-up, assessing the presence of pseudarthrosis or delayed bone union and evaluating functional outcomes with the Anderson and the Disability of the Arm, Shoulder and Hand scale. RESULTS: Clinical and radiological bone union was achieved in an average of 12 weeks. We obtained 77% of excellent and good results following Anderson's scale. There were 4 cases of pseudarthrosis and 6 cases of delayed bone union. CONCLUSION: This surgical technique provides several advantages, such as a low incidence of complications and a total absence of infections, refractures and iatrogenic neurovascular injuries. It allows a lower hospital stay and a shortening of the surgery time compared with other techniques such as plates and intramedullary nails, that have similar results, in terms of bone union and functional outcomes, as we have verified from the published literature.


Assuntos
Fixação Intramedular de Fraturas/métodos , Fraturas do Rádio/cirurgia , Fraturas da Ulna/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Fios Ortopédicos , Diáfises/diagnóstico por imagem , Diáfises/lesões , Diáfises/cirurgia , Feminino , Seguimentos , Fixação Intramedular de Fraturas/instrumentação , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Fraturas do Rádio/diagnóstico por imagem , Estudos Retrospectivos , Resultado do Tratamento , Fraturas da Ulna/diagnóstico por imagem , Adulto Jovem
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