RESUMO
A new series of benzhydryloxyalkylpiperazines carrying a trivalent function has been synthesized and studied for its effects on the central nervous system. Most of the compounds exhibit unexpected nonamphetaminic psychoanaleptic properties. The structure-activity studies revealed the importance of the nature and the position of the substituents on the phenyl rings. However, no significant correlation between atropinic or antihistaminic effects and psychoanaleptic properties was observed.
Assuntos
Estimulantes do Sistema Nervoso Central/síntese química , Difenidramina/análogos & derivados , Animais , Depressores do Apetite/síntese química , Difenidramina/síntese química , Difenidramina/farmacologia , Difenidramina/toxicidade , Cães , Comportamento Exploratório/efeitos dos fármacos , Feminino , Cobaias , Antagonistas dos Receptores Histamínicos H1/síntese química , Dose Letal Mediana , Masculino , Camundongos , Parassimpatolíticos/síntese química , Ratos , Sono/efeitos dos fármacos , Relação Estrutura-Atividade , Simpatomiméticos/síntese químicaRESUMO
In the female rat intoxicated with ethylene glycol the oxaluria increases with the degree of intoxication. The increase is less in the animals treated with succinimide. The comparative study of the results of the dosages made with gas-liquid-chromatography and by various colorimetric methods show that this later gives varying results and underestimates high concentrations of oxalic acid. The result is that any study based on results of dosages of urinary oxalic acid made by colorimetry must be taken with some reserve, and this on whether the oxalic lithiasis is experimentally induced or human, or whether its evolution is spontaneous or influenced by a therapeutic.
Assuntos
Oxalatos/urina , Succinimidas/farmacologia , Animais , Colorimetria/métodos , Colorimetria/normas , Etilenoglicóis , Feminino , Oxalatos/análise , RatosAssuntos
Tiazóis/síntese química , Animais , Cobaias , Técnicas In Vitro , Camundongos , Coelhos , Ratos , Tiazóis/farmacologiaRESUMO
An experimental study made on rat shows an inhibitrice activity of succinimide on formation of others kinds of urinary stones than those constituted with Ca oxalate and suggests the existence of a non specific anticrystallizing effect.
