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Pathol Biol (Paris) ; 59(1): 44-7, 2011 Feb.
Artigo em Francês | MEDLINE | ID: mdl-20889268

RESUMO

Candida parapsilosis is a normal saprophyte of the skin, characterized by their affinity for catheters. This species has, in vitro, a level of sensitivity against the echinocandins, significantly lower than that observed with other Candida species. Recently, new species: Candida orthopsilosis and Candida metapsilosis, phenotypically identical to C. parapsilosis, have been identified by molecular biology. From 2003 to 2007, in the Cochin hospital, the proportion of C. parapsilosis among non-albicans species isolated from blood cultures increased from 17 (3/18) to 38% (5/13). To understand the reasons for this emergence, we retrospectively characterized isolates, conducted a case-control and researched a link between the emergence and introduction of caspofungin in our hospital. We analysed data from 26 patients who had candidemia with C. parapsilosis. Genotypic analysis of isolates has not identified the new species C. orthopsilosis and C. metapsilosis. The case-control study showed a broad-spectrum antibiotics was significantly more frequent for candidemia with C. parapsilosis compared to C. albicans (52 versus 26%, P=0.04) as a previous treatment with caspofungin (11 versus 0%, P=0.04). The introduction of caspofungin is contemporary with the emergence of candidemia with C. parapsilosis with a tendency to be related to its level of consumption in the ICU. Our results should encourage biologists to closely monitor the frequency and level of sensitivity of strains of C. parapsilosis isolated in hospital.


Assuntos
Candida/isolamento & purificação , Candidemia/epidemiologia , Infecção Hospitalar/epidemiologia , Hospitais Públicos/estatística & dados numéricos , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/efeitos adversos , Antibacterianos/uso terapêutico , Antifúngicos/efeitos adversos , Antifúngicos/uso terapêutico , Candida/efeitos dos fármacos , Candidemia/microbiologia , Estudos de Casos e Controles , Caspofungina , Infecções Relacionadas a Cateter/epidemiologia , Infecções Relacionadas a Cateter/microbiologia , Infecção Hospitalar/microbiologia , Suscetibilidade a Doenças , Farmacorresistência Fúngica , Uso de Medicamentos/estatística & dados numéricos , Equinocandinas/efeitos adversos , Equinocandinas/uso terapêutico , Feminino , Humanos , Lipopeptídeos , Masculino , Pessoa de Meia-Idade , Morbidade/tendências , Paris/epidemiologia , Estudos Retrospectivos , Risco , Fatores de Risco , Especificidade da Espécie , Adulto Jovem
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