1.
Bioorg Med Chem Lett
; 14(12): 3057-61, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15149644
RESUMO
The synthesis of a novel series of 1,7-annulated indolocarbazoles 2 and 16 is described. These compounds were found to be potent cyclin dependent kinase inhibitors with good antiproliferative activity against two human carcinoma cell lines. These inhibitors also arrested tumor cells at the G1 phase and inhibited pRb phosphorylation.