1.
J Org Chem
; 72(6): 2127-32, 2007 Mar 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17295544
RESUMO
A stannane-free hydrodehalogenation of 4-halotetrahydropyran under very mild conditions has been developed. This methodology allows selective one-pot dehalogenation and/or debenzylation depending on the type of halide-substrate used. The applicability of this methodology is well demonstrated in the synthesis of a key intermediate toward the enantioselective synthesis of (+)-SCH 351448.