1.
Org Lett
; 21(19): 7746-7749, 2019 10 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31532216
RESUMO
A one-pot method for joining three separate components leading to an assortment of N-substituted 3,4-dihydro-2H-1,3-benzoxazines is described. The method involves the addition of a Grignard reagent to an o-OBoc salicylaldehyde in the presence of an imine. With a variety of components, 15 examples are presented, including the diastereoselective incorporation of chiral imines.