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1.
J Undergrad Neurosci Educ ; 21(2): A85-A90, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37588643

RESUMO

Neuroscience is inherently interdisciplinary. This interdisciplinarity can be lost due to the self-contained nature of each course in most undergraduate neuroscience programs, leaving students to draw these cross-course relationships on their own. We sought to address this by using short, creative research assignments on a topic of the student's choice ("Deep Dive" assignments) that provided students with the opportunity to explore common applications across two concurrently run core neuroscience courses housed in different departments. We tested whether unifying the available Deep Dive topics across the two courses improved student outcomes. Specifically, students were asked to select a topic of interest from a shortlist shared in the two courses. Our results show that harmonized, concurrent creative assignments across dissimilar neuroscience courses improved outcomes related to student interest in material, confidence in creative problem solving, content recall for the other course, and applicability to real life. To our surprise, there was no added benefit to be in the same topic for both courses. Instead, the addition of harmonized Deep Dive assignments themselves, even if assigned on different topics across the two courses, drove the outcome improvement.

2.
Psychol Res ; 86(2): 544-557, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33683449

RESUMO

Speech perception in noise is a cognitively demanding process that challenges not only the auditory sensory system, but also cognitive networks involved in attention. The predictive coding theory has been influential in characterizing the influence of prior context on processing incoming auditory stimuli, with comparatively less research dedicated to "postdictive" processes and subsequent context effects on speech perception. Effects of subsequent semantic context were evaluated while manipulating the relationship of three target words presented in noise and the temporal position of targets compared to the subsequent contextual cue, demonstrating that subsequent context benefits were present regardless of whether the targets were related to each other and did not depend on the position of the target. However, participants instructed to focus on the relation between target and cue performed worse than those who did not receive this instruction, suggesting a disruption of a natural process of continuous speech recognition. We discuss these findings in relation to lexical commitment and stimulus-driven attention to short-term memory as mechanisms of subsequent context integration.


Assuntos
Ruído , Percepção da Fala , Humanos , Memória de Curto Prazo , Semântica , Fala
3.
Psychopharmacology (Berl) ; 238(2): 475-486, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33150479

RESUMO

RATIONALE AND OBJECTIVES: The reinforcement-enhancing effect (REE) of nicotine refers to the drug's ability to enhance the strength of other primary and conditioned reinforcers. The main aim was to investigate neuropharmacological mechanisms underlying nicotine's strengthening of a primary visual reinforcer (i.e., a light cue), using a subcutaneous (SC) dose previously shown to provide plasma nicotine levels associated with habitual smoking. METHODS: Adult male rats pressed an "active" lever to illuminate a brief cue light during daily 60-min sessions. Rats that showed a clear REE were tested with systemically administered pretreatment drugs followed by nicotine (0.1 mg/kg SC) or saline challenge, in within-subject counterbalanced designs. Pretreatments were mecamylamine (nicotinic, 0.1-1 mg/kg SC), SCH 39166 (D1-like dopaminergic, 0.003-0.2 mg/kg SC), naloxone (opioid, 1 and 5 mg/kg SC), prazosin (alpha1-adrenergic antagonist, 1 and 2 mg/kg IP), rimonabant (CB1 cannabinoid inverse agonist, 3 mg/kg IP), sulpiride (D2-like dopaminergic antagonist, 40 mg/kg SC), or propranolol (beta-adrenergic antagonist, 10 mg/kg IP). RESULTS: The nicotine REE was abolished by three antagonists at doses that did not impact motor output, i.e., mecamylamine (1 mg/kg), SCH 39166 (0.01 and 0.03 mg/kg), and naloxone (5 mg/kg). Prazosin and rimonabant both attenuated the nicotine REE, but rimonabant also suppressed responding more generally. The nicotine REE was not significantly altered by sulpiride or propranolol. CONCLUSIONS: In adult male rats, the reinforcement-enhancing effect of low-dose nicotine depends on nicotinic receptor stimulation and on neurotransmission via D1/D5 dopaminergic, opioid, alpha1-adrenergic, and CB1 cannabinoid receptors.


Assuntos
Nicotina/farmacologia , Antagonistas Nicotínicos/farmacologia , Receptores Nicotínicos/metabolismo , Reforço Psicológico , Antagonistas de Receptores Adrenérgicos alfa 1/farmacologia , Antagonistas Adrenérgicos beta/farmacologia , Animais , Benzazepinas/farmacologia , Condicionamento Operante , Antagonistas de Dopamina/farmacologia , Relação Dose-Resposta a Droga , Masculino , Mecamilamina/farmacologia , Prazosina/farmacologia , Propranolol/farmacologia , Ratos
4.
Brain Res ; 1751: 147206, 2021 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-33189693

RESUMO

It is well established that identification of words in noise improves when it is preceded by a semantically related word, but comparatively little is known about the effect of subsequent context in guiding word in noise identification. We build on the findings of a previous behavioural study (Chan & Alain, 2019) by measuring neuro-electric brain activity while manipulating the semantic content of a cue that either preceded or followed a word in noise. Participants were more accurate in identifying the word in noise when it was preceded or followed by a cue that was semantically related. This gain in accuracy coincided with a late positive component, which was time-locked to the word in noise when preceded by a cue and time-locked to the cue when it followed the word in noise. Distributed source analyses of this positive component revealed different patterns in source activity between the two temporal conditions. The effects of relatedness also generated an event-related potential modulation around 400 ms (N400) that was present at cue presentation when it followed the word in noise, but not for the word in noise when preceded by the cue, consistent with findings regarding its sensitivity to signal degradation. Exploratory analyses examined a subset of data based on participants' subjective perceived clarity, which revealed a posterior deflection over the left hemisphere that showed a relatedness effect. We discuss these findings in light of research on prediction as well as a reflective attention framework.


Assuntos
Atenção/fisiologia , Percepção Auditiva/fisiologia , Percepção da Fala/fisiologia , Adulto , Encéfalo/fisiologia , Sinais (Psicologia) , Eletroencefalografia/métodos , Potenciais Evocados/fisiologia , Feminino , Humanos , Masculino , Ruído , Semântica , Som , Adulto Jovem
5.
Atten Percept Psychophys ; 81(1): 253-269, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30187397

RESUMO

The ephemeral nature of spoken words creates a challenge for oral communications where incoming speech sounds must be processed in relation to representations of just-perceived sounds stored in short-term memory. This can be particularly taxing in noisy environments where perception of speech is often impaired or initially incorrect. Usage of prior contextual information (e.g., a semantically related word) has been shown to improve speech in noise identification. In three experiments, we demonstrate a comparable effect of a semantically related cue word placed after an energetically masked target word in improving accuracy of target-word identification. This effect persisted irrespective of cue modality (visual or auditory cue word) and, in the case of cues after the target, lasted even when the cue word was presented up to 4 seconds after the target. The results are framed in the context of an attention to memory model that seeks to explain the cognitive and neural mechanisms behind processing of items in auditory memory.


Assuntos
Atenção/fisiologia , Sinais (Psicologia) , Memória de Curto Prazo/fisiologia , Ruído , Fonética , Percepção da Fala/fisiologia , Estimulação Acústica/métodos , Adolescente , Adulto , Percepção Auditiva/fisiologia , Feminino , Audição/fisiologia , Humanos , Masculino , Estimulação Luminosa/métodos , Adulto Jovem
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