Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Assunto principal
Intervalo de ano de publicação
1.
J Am Chem Soc ; 145(16): 9003-9010, 2023 04 26.
Artigo em Inglês | MEDLINE | ID: mdl-37040604

RESUMO

The infection of Campylobacter jejuni results in a significant diarrhea disease, which is highly fatal to young children in unindustrialized countries. Developing a new therapy is required due to increasing antibiotic resistance. Herein, we described a total synthesis of a C. jejuni NCTC11168 capsular polysaccharide repeating unit containing a linker moiety via an intramolecular anomeric protection (iMAP) strategy. This one-step 1,6-protecting method structured the challenging furanosyl galactosamine configuration, facilitated further concise regioselective protection, and smoothed the heptose synthesis. The tetrasaccharide was constructed in a [2 + 1 + 1] manner. The synthesis of this complicated CPS tetrasaccharide was completed in merely 28 steps, including the preparation of all the building blocks, construction of the tetrasaccharide skeleton, and functional group transformations.


Assuntos
Campylobacter jejuni , Criança , Humanos , Pré-Escolar , Polissacarídeos , Heptoses , Oligossacarídeos , Cápsulas Bacterianas
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...