RESUMO
OBJECTIVE: To study the prevalence of aspirin resistance in cerebrovascular disease patients in Phramongutklao hospital. MATERIAL AND METHOD: The acute ischemic and stable stroke patients who received aspirin at least 60 mg, at least 7 days and the last dose of aspirin at least 24 hours before blood test for platelet aggregation. ADP and Collagen were used as platelet aggregator. RESULTS: During July 2007- December 2008, 141 cases of ischemic stroke were enrolled. "Aspirin resistant" was defined as mean aggregation more than 60% both ADP and Collagen. "Aspirin semi-responder" was mean aggregation less than 60% for ADP or Collagen. CONCLUSION: Prevalence of aspirin resistance in Phramonkutklao hospital is 56 % (79/141), and there are relationship between aspirin resistance and timing in the first episode of stroke.
