1.
Planta Med
; 64(3): 281-2, 1998 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9581528
RESUMO
Chromatographic separation of the EtOH extract of the bark of Garcinia dulcis (Guttiferae) furnished five xanthones, viz 1,7-dihydroxyxanthone (1), 12b-hydroxy-des-D-garcigerrin A (2), 1-O-methylsymphoxanthone (3), symphoxanthone (4), and garciniaxanthone (5). These xanthones 1-5 showed inhibitory effects on the growth of Plasmodium falciparum with IC50 values of 0.96-3.88 micrograms/ml. In addition, revised 13C-NMR assignments of 3 and complete 13C-NMR assignments of 4 were obtained through analysis of their COSY, NOESY, HMQC, and HMBC spectra.
Assuntos
Antimaláricos/isolamento & purificação , Antimaláricos/farmacologia , Xantenos/isolamento & purificação , Xantenos/farmacologia , Animais , Espectroscopia de Ressonância Magnética , Modelos Químicos , Plasmodium falciparum/efeitos dos fármacos
2.